- Amlitelimab, an investigational IRAK4 degrader, showed significant improvements in signs and symptoms of atopic dermatitis in a Phase 2b trial. At week 16, 40.3% of patients achieved EASI-75 with amlitelimab vs 11.4% with placebo, and 22.1% achieved IGA 0/1 vs 5.1% with placebo.
- At week 24, amlitelimab continued to show benefits over placebo with 54.5% achieving EASI-75 vs 17.7% for placebo, and 45.5% achieving IGA 0/1 vs 11.4% for placebo.
- Amlitelimab
This document provides an overview of the state of the influencer marketing industry in 2022 based on surveys of over 2,000 marketing professionals. Some key findings include: influencer marketing is expected to grow to $16.4 billion in 2022; three-quarters of respondents intend to dedicate a budget to influencer marketing in 2022; and the most common challenge for those running campaigns in-house is measuring ROI and campaign results. The report aims to provide benchmarks, metrics, and data on influencer marketing to help inform future campaigns.
Starbucks' social media priorities for 2016-2017 are to increase engagement and followers. Three strategies will support this: increasing shares/likes/comments; encouraging online conversations; and publishing interactive content. Instagram receives the most interactions per post. Facebook and Twitter are the top traffic drivers but LinkedIn and Pinterest drive little traffic. The objectives are to increase comments/mentions replies and followers across platforms. Key messages are being social, responsible drinks, seasonal themes, and fun connections. Engagement and followers will be measured quarterly.
This document summarizes information about lichen planus, a common skin condition. Lichen planus appears as clusters of flat-topped bumps that are the same color as or pinkish compared to the surrounding skin. It most often occurs on the chest, abdomen, arms, and genitals. While the initial cause is unknown, it involves inflammation controlled by immune cells. Lichen planus usually clears up on its own within a few months, but it may cause permanent skin discoloration and, rarely, increase cancer risk. Treatment options include corticosteroids, retinoids, or phototherapy prescribed by a doctor.
The document discusses the performance and metrics of the All of Us media campaigns. It provides details on campaign objectives, goals and KPIs such as CTR, CVR, and CPA. It summarizes the reach, website traffic, and number of estimated account conversions for both the national campaign and co-branded campaign. Predictive modeling estimates the national campaign has achieved between 14,088 to 28,446 account conversions with a CPA range of $72 to $35. The campaigns have been successful in creating program awareness, interest and filling the website funnel with new traffic.
Retinoids are compounds that have structural or functional similarities to vitamin A. They are classified based on their structure and mechanism of action. Common forms include isotretinoin, acitretin, and bexarotene. Retinoids are FDA approved for severe acne and cancer but are also used for other conditions like rosacea, psoriasis, and keratinization disorders. Side effects include mucocutaneous dryness and hyperlipidemia. Strict monitoring guidelines must be followed due to teratogenicity risks, including effective contraception for women of childbearing age.
This document provides an overview of developing a social media strategy. It discusses key concepts such as defining social media, its history, and why businesses use it. The document then outlines a six-level approach to creating a social media strategy: 1) Setting goals, 2) Understanding your audience, 3) Defining your brand, 4) Planning content, 5) Creating content, and 6) Analyzing and measuring. Each level includes questions to consider. Finally, the document provides examples of successful social media strategies from companies like Air Asia, Taco Bell, Coca-Cola, and Nike.
Prurigo is a group of skin diseases characterized by intensely itchy papules or nodules without an identifiable local cause. It is caused by severe chronic itching leading to repetitive scratching and skin irritation. This results in a lymphocyte-rich inflammatory infiltrate, activated keratinocytes and sensory nerves, and increased collagen tissue.
Prurigo nodularis specifically presents as intensely itchy nodules on the extremities. Histology shows hyperkeratosis, acanthosis, and proliferation of cutaneous nerves and fibroblasts. Treatment focuses on eliminating pruritus through antipruritic medications and phototherapy to break the itch-scratch cycle and reduce inflammation.
Bcg cii report - one consumer, many interactions - december 2018Social Samosa
The report highlights the massive, unparalleled change the media and entertainment industry is going through, with the exponential growth of media and type of content available creating a trillion customer touch points.
Creating Engaging Videos: Everything You Need To Know To Produce Authentic Co...Tinuiti
In this session, we partnered with video creative agency ReadySet to talk about how to create engaging, authentic videos that work across platforms, and how to measure their performance.
Digital 2023 Germany (February 2023) v01DataReportal
This document provides an overview and summary of global digital trends in 2023, including statistics on population, mobile and internet connectivity, and social media usage. Some key highlights include:
- The world population was 8.01 billion as of 2023, with over 5 billion internet users, representing year-on-year growth rates of 0.8% and 2.2% respectively.
- Active social media usage reached 4.76 billion - a 3.0% increase from 2022. However, social media user figures may overestimate unique individuals and are not comparable to past reports due to data changes.
- Internet penetration and social media usage varied widely by world region, from under 25% in parts of
The document discusses social media trends for 2023. It notes that TikTok has cemented itself as the dominant platform and is rewriting industry rules by prioritizing organic content and participation. Organic and earned efforts are making a comeback as platforms like Facebook and YouTube see declining revenues and engagement. Brands are taking a more channel-agnostic approach and focusing on engagement and community building rather than uniform strategies across platforms.
New Era. New Opportunities.
Devastating in so many ways, it cannot be denied that the pandemic has also been deeply transformative, accelerating new ways of living, working and thinking across almost every layer of our lives. Social is no exception.
At Punch, we’ve seen explosive growth in areas like intimate live social events, tutorials, workshops and shoppable content, as brands seek to add value to their customers’ lives and form deeper, longer-lasting connections with their followers.
Where the past decade has seen us confronting the more challenging aspects of social, things like data privacy, mental health and politics, 2021 has given us plenty of exciting signals that point towards a new era of social that starts right now – Web 3.0. With new opportunities coming at brands left, right and centre, we’re about to see a deep shift, with creators and innovators taking the reins and decentralising the power held by the big blue platforms since the mid-noughties.
In this report, we naturally discuss the emerging vision of the metaverse. The metaverse represents huge opportunity for brands; for some, early adoption might prove to be a key strategic investment. But the metaverse isn’t what excites us at the moment (sorry Zuck). With revolution in the air, we want to know what the underdogs are doing: the tech dreamers, the NFT kids, the creators. As creators become more and more valued for the central role they play in making social a fun place to be, we are already seeing examples of individuals breaking away and building their own niche communities. Whether they start to take large swathes of the larger platforms’ audiences with them remains to be seen. What can brands learn from their thinking – and how can we forge better and more creative partnerships? This is the big question of 2022.
Certain trends from last year, notably s-commerce and live video, are back for another year. The challenge with video is how to leverage new tools and techniques to create video content at scale in fresh, creative and authentic ways. We’re also starting to see audiences being actively rewarded for their loyalty and engagement, with highly-creative community managers and efficient and proactive customer service teams. Web 3.0 is unfolding; a bolder, fairer and more democratic digital playground where creativity and loyalty trump all. As user numbers grow and platforms and audiences mature further, budgets are likely to shift towards a combination of acquisition AND driving loyalty and retention.
“Community” is our key buzzword for 2022. Whether you’re getting in on the ground floor of branded NFT “moments”, exploring the hotter- and-hotter world of gaming, or investing more in cinematic video, success will depend on centring your community, acting thoughtfully and, as always, creating difference with mind blowing content and standout campaigns.
This document discusses key concepts for social media market segmentation including behavioral segmentation models, buyer personas, and social influences. It describes segmentation as dividing a market into groups with common needs and characteristics. Marketers then target specific segments. The document outlines segmentation bases like demographics and discusses models for social media segmentation. It emphasizes understanding target segments' social media behaviors and influencers to inform marketing. Community characteristics like groups, participation, and influencers can impact how brands engage on social platforms.
Atopic dermatitis is a common inflammatory skin condition characterized by itchy, red lesions. It has a complex pathogenesis involving skin barrier dysfunction, immune dysregulation with Type 2 inflammation, and microbial dysbiosis. Genetic factors like filaggrin mutations contribute to impaired skin barrier function. Colonization by Staphylococcus aureus and Malassezia yeasts further damages the skin and promotes inflammation. Pruritus (itching) activates scratch responses that sustain the condition through additional skin damage and inflammation. Treatment involves managing symptoms, restoring skin barrier function, and controlling inflammation and infection.
Metaverse In Healthcare Can Be The Next Big Thing? Techugo
The amalgamation of metaverse in healthcare is going to be the trend of the future!
Really?
Witness the same yourself by exploring the PPT, and to know about healthcare app development, visit https://www.techugo.com/healthcare-app-development.
With the changing A & M Industry, the CII BCG report highlights key factors and lays the path forward for the industry to achieve new growth during the rapid transformation in the digital age and time over the next decade.
The document provides an overview and key takeaways from Activate Technology & Media Outlook 2022. Some of the main points covered in the 14 takeaways include:
- Consumer spend on technology and media increased during the pandemic and more time spent will lead to new opportunities for growth.
- Cryptocurrency usage will double in the next year as consumers move from investment to payments/transfers, though Bitcoin and Ethereum dominate currently.
- NFTs will become a mainstream behavior as many industries create and trade them.
- Video games are leading to the metaverse as most digital activities will take place within games.
- The pursuit of the metaverse will drive extensive technology and experience investments by
This document summarizes an economic forum held by the Office for National Statistics (ONS). It includes the following:
- An agenda for presentations on the state of the UK economy, factors driving inflation, discretionary spending over winter, and a question and answer session.
- A presentation by the ONS Chief Economist giving an overview of the UK economy, noting that growth forecasts still point to a challenging 2023, with industrial action and higher economic inactivity as issues.
- A presentation by an ONS analyst discussing how both reopening of the economy (increasing demand) and supply bottlenecks have contributed to inflation in the UK since the pandemic, though these impacts are falling.
- A presentation
1) The document discusses benchmarks, budgets, and trends for technology content marketing in 2022 based on a survey.
2) It finds that nearly one-third of technology marketers rated their content marketing success as "extremely" or "very" successful over the past year. Top performers stand out through differentiating content and prioritizing audience needs.
3) Creating content for multi-level roles, accessing subject matter experts, and internal communication were the top challenges reported. Most technology marketers plan to invest in video content in 2022.
Sanofi reported its Q4 and full year 2022 results with strong growth. The document discusses Sanofi's strategy execution which delivered growth and margin expansion through 2022. It provides an agenda for the investor relations presentation covering a business update on specialty care, vaccines, GenMed and consumer healthcare performance in Q4 2022 as well as the financial performance and outlook for 2023.
Sanofi reported strong Q2 2022 results, with Dupixent sales nearly reaching €2 billion. Dupixent continues its outstanding performance with 43.4% sales growth year-over-year, driven by new indications and approvals in both the US and EU. Sanofi's pipeline is advancing with regulatory submissions for efanesoctocog alfa and nirsevimab expected in 2022. Positive data was also reported for the company's Beta-containing COVID-19 vaccine against variants including Omicron.
Sanofi reported Q3 2022 results with sales growing 9.0% driven by strong performances from Specialty Care and Vaccines. Dupixent sales grew 44.5% from new launches in indications like EoE and younger populations. Vaccines sales increased 23.5% on growth of flu vaccines and recovery of travel vaccines. The document notes several forward-looking statements and risks that could impact projections. Upcoming newsflow over the next 18 months includes data readouts from late-stage trials in areas like oncology, immunology, and vaccines.
This document provides an agenda and summaries for Sanofi's Q4 2023 results presentation. The agenda includes sections on R&D update, Biopharma update, Consumer Healthcare update, Growth engine outlook for 2024, and Financial performance. Some key highlights include:
- Specialty Care and Vaccines drove strong growth, with Dupixent sales adding €2.8 billion.
- 2023 launches exceeded sales expectations, bringing in over €2.2 billion combined.
- The pipeline has numerous expected milestones in 2024, including Dupixent COPD approval and results from multiple Phase 2 and 3 trials.
- An acquisition of INBRX-101 was announced to add an innovative asset for
- Sanofi reported Q2 2023 results with total sales up 3.3% driven by double-digit growth of Specialty Care led by Dupixent and strong growth in Vaccines, while CHC was impacted by a Q1 inventory build.
- Specialty Care sales increased 11.8% led by 34.2% growth of Dupixent which saw demand-driven growth across its five approved indications. Rare Diseases grew 9.6% mainly due to patient accruals in Fabry and Pompe franchises and the strong launch of Nexviazyme. Neurology, Oncology and Rheumatology declined 35.1% due to LOE impact on Aubagio.
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- Sanofi reported Q3 2020 results with total sales of €9.5 billion, up 5.7% year-over-year at CER.
- Dupixent sales grew 69% to €918 million driven by strong performance in atopic dermatitis and asthma.
- Vaccines sales increased 14% to €2.1 billion due to a record flu season with over 80 million doses delivered in the US.
- General Medicines sales declined 7% to €3.6 billion due to anticipated price impacts in China, while Diabetes sales declined by low single digits globally.
The document provides an update on Sanofi's Q1 2023 results and outlook. It discusses strong growth in Specialty Care driven by Dupixent and vaccines. Dupixent sales grew 40% in Q1 supported by new indications. Positive Phase 3 data was announced for Dupixent in COPD. The pipeline includes 12 novel molecules in immunology. Tofezimbab is progressing in multiple sclerosis trials. The document outlines the strategy to leverage innovation and drive growth to 2030.
- Sanofi reported Q1 2022 results with sales growth of 8.6% and earnings per share growth of 16.1%.
- Dupixent sales increased 45.7% driven by strong performance across indications.
- Vaccines sales grew 6.8% led by pertussis-containing vaccines in China and higher sales of travel and endemic vaccines.
- The company advanced its pipeline during the quarter with regulatory submissions and trials across core therapeutic areas.
This document provides a summary of Sanofi's Q4 and full year 2019 results. It includes sections on business updates from the CEO, R&D updates, and financial updates. Some key highlights include Dupixent sales reaching €2.1 billion in 2019, pipeline progress such as positive proof-of-concept data for BTKi in multiple sclerosis, and full year sales growing 2.8% to €36 billion. The document also outlines priorities for 2020 such as expanding Dupixent indications and influenza vaccine differentiation in the US.
The document provides an overview of Sanofi's Q4 and full year 2021 results. Key highlights include:
- Global sales grew 7.1% in 2021 to €37.7 billion, driven by strong growth of Specialty Care which became the largest business unit.
- Dupixent sales increased 53% in Q4 to €1.55 billion, with growth across all regions. Prurigo nodularis phase 3 trials showed significant improvements.
- Vaccines sales declined 6.5% in Q4 due to earlier seasonal flu shipments, while full year flu vaccine sales reached record levels in 2021.
- Planned launches of sutimlimab for CAD in 2022 and olp
Play to Win Q2 2021 Results
- Sanofi reported sales of €8.7 billion in Q2 2021, up 12% year-over-year, and business EPS of €1.38, up 16% year-over-year.
- Dupixent sales grew 57% year-over-year to €1.2 billion, driven by strong performance in both the US and ex-US markets.
- Vaccines sales increased by double digits to €1 billion in Q2 2021 compared to the same period in 2020.
- The presentation reviewed Sanofi's progress on priority R&D assets and initiatives to increase diversity and inclusion in the workplace.
Play to Win is Sanofi's Q3 2021 results document. It summarizes strong sales and earnings growth in Q3 2021 driven by 10% sales growth and 19% growth in business EPS. Key drivers included a 55% increase in Dupixent sales to €1.41 billion. Vaccines also saw record sales. Sanofi raised its full-year 2021 business EPS growth guidance to 14% due to the outstanding quarterly performance. The document discusses Sanofi's strategy of pursuing bolt-on acquisitions to strengthen key areas and pipeline progress, and provides an overview of segment performance in Q3.
This document provides an overview of Novartis' Q3 2021 results investor presentation. It includes sections on company overview, financial performance, key growth drivers, and an announcement to commence a strategic review of the Sandoz division to maximize shareholder value. The strategic review will explore options ranging from retaining Sandoz to a potential separation, and an update will be provided by the end of 2022.
- Q3 2017 company sales grew 4.7% at CER to €9.1 billion, driven by specialty care and vaccines franchises. Diabetes sales declined 14.8% due to losses of exclusivity.
- Specialty care grew 13.9% led by strong Dupixent sales in the US and Kevzara gaining 15% of the IL-6 market share. Vaccines grew 7.2% with strong pediatric combination vaccine sales.
- Consumer healthcare grew 1% with emerging markets up 6.7% offsetting declines in developed markets due to increased competition.
Quintiles william blair-35th-annual-growth-stock-conferencepatyi_2000
This document provides an overview of Quintiles, a leader in biopharma services. It discusses Quintiles' two business segments: Product Development services and Integrated Healthcare Services. Product Development services represent the majority of Quintiles' business and includes clinical research services from Phase I-IV. Integrated Healthcare Services includes commercialization services, real-world research, and other healthcare solutions. The document notes that the biopharma market is large, growing, and increasingly outsourcing services. It highlights drivers in the market that play to Quintiles' strengths and differentiated offerings across both segments.
Sanofi reported its Q2 2020 results, highlighting a 9.2% increase in EPS driven by strong Dupixent sales growth of 94%. While most business units saw impacts from COVID-19, Dupixent maintained momentum with new launches and indications. Sanofi also progressed its pipeline including initiating Phase 3 for BTK inhibitor '168 in multiple sclerosis.
- Q1 2020 sales were €8.973 billion, up 6.6% driven by strong Dupixent sales growth.
- Dupixent sales increased 130% to €776 million and continue to see double-digit growth.
- Specialty Care sales were up 31.3% led by Dupixent while General Medicines sales fell 3.8% due to COVID-19 stocking and China's VBP program.
Sanofi reported Q2 2017 results, with key highlights including:
- Sales of €8.6 billion, up 0.6% at CER. Specialty care and vaccines grew, while diabetes sales declined.
- Business EPS grew 1.5% to €1.35 per share.
- Dupixent had strong launch, generating €26 million in sales. Kevzara was launched in the US and Europe.
- Vaccines sales grew 19.2% driven by pediatric combinations and Menactra.
- Diabetes sales declined 15% due to US challenges, partially offset by Toujeo growth.
- Emerging markets continued strong growth, while developed markets faced some headw
Valeant Pharmaceuticals announced its acquisition of Bausch + Lomb to create a global leader in eye health. The $8.7 billion deal will make Valeant a top competitor in ophthalmic pharmaceuticals, surgical products, and vision care. Valeant expects to achieve at least $800 million in cost synergies by the end of 2014. The combined company will have a strong presence across major eye health segments and geographies, with leadership in attractive emerging markets.
This document contains forward-looking statements regarding Sanofi's strategic outlook, key growth drivers, and pipeline of potential transformative therapies. It discusses the significant growth potential of Dupixent across type 2 inflammatory diseases, with an ambition to achieve over €10 billion in peak sales. Vaccines are also highlighted as an expected mid-to-high single-digit growth driver through 2025. The pipeline includes potential first-in-class or best-in-class therapies for diseases like multiple sclerosis, respiratory syncytial virus, and breast cancer that could transform patient care if approved.
Sanofi reported solid financial results for Q2 2023, with sales increasing 3.3% to €9,965 million and business earnings per share growing 8.1% to €1.74. By business unit, Specialty Care saw the highest sales of €4,403 million, followed by General Medicines at €3,114 million and Vaccines at €1,223 million. Geographically, the United States was the largest market with sales of €3,919 million. Sanofi also highlighted several positive clinical trial readouts, including FDA approval of their RSV prevention treatment for newborns and infants, positive phase 3 data for a COPD biologic, and positive phase 2b results for
Sanofi reported strong Q1 2023 results, with specialty care sales up 18.3% driven by Dupixent growth of 39.7%. Vaccines sales also grew 15.2% from COVID contracts and travel vaccine recovery. R&D updates included positive Dupixent COPD data and promising early immunology assets. The document provided financial and business performance summaries for Q1 2023 and outlook.
Sanofi reported strong Q1 2023 results, with sales growth of 5.5% overall. The Specialty Care unit grew 18.3% driven by Dupixent sales increasing 39.7%. Dupixent continues to see strong demand globally. Vaccines sales grew 15.2% from COVID contracts and travel/booster vaccine recovery. R&D advancements included positive Dupixent COPD data and upcoming events for fitusiran and tolebrutinib. Financial guidance and outlook will be provided later in the year.
Sanofi reported strong financial results for 2022, with company sales growing 7.0% to €42,997 million and business EPS increasing 17.1% to €8.26. The company will continue investing in science as it launches the next phase of its strategy to maintain progress developing first and best in class medicines. Recent regulatory approvals in Europe include treatments for prurigo nodularis, a COVID-19 booster vaccine, prevention of respiratory syncytial virus in infants, and cold agglutinin disease.
Sanofi delivered strong third quarter results with sales growth of 9.0% and business EPS growth of 17.9%. The company achieved key regulatory milestones for three of its priority medicines and its commitment to breakthrough science is bearing fruit. Paul Hudson, Chief Executive Officer, noted that the results demonstrate Sanofi is on the right path.
Sanofi reported €9,674 million in company sales for Q1 2022, an increase of 8.6% at constant exchange rates. The company's CEO noted they made progress in immunology with 13 potential new treatments in development. Specialty Care was Sanofi's largest global business unit by sales in Q1 2022, generating €3,566 million, followed by General Medicines with €3,760 million.
Sanofi reported its Q4 and full year 2021 results. The document contains forward-looking statements and discusses Sanofi's Q4 performance, pipeline progress, and planned upcoming launches. Key highlights include Specialty Care becoming Sanofi's largest business unit driven by strong Dupixent sales of €1.5 billion in Q4. The pipeline was also strengthened with the addition of 36 projects in phase I/II.
Presentation Part 2 – Leading with innovationSanofi
Sanofi is building an innovative and diversified vaccine pipeline by expanding into new disease areas and technologies. They have added mRNA and LNP platforms and have 10 new development candidates by 2025, including 6 mRNA vaccines. Sanofi is focusing on first-in-class or best-in-class vaccines and leveraging immunology, antigen design, and the best technology for each target. They are broadening their pipeline to address additional chronic diseases and expanding populations.
Presentation Part 1 – Growing current business Sanofi
Sanofi is focused on growing its vaccines business by winning in influenza, launching nirsevimab to protect all infants against RSV, and unlocking the potential of mRNA technology. The company aims to more than double its vaccines sales by the end of the decade through continued expansion of existing franchises like influenza, entry into new areas like pneumococcal vaccines, and delivery of new mRNA vaccine candidates. Sanofi believes it has the capabilities needed to succeed, including best-in-class vaccines, large-scale manufacturing and supply expertise, and a strengthening pipeline.
The document summarizes Q1 2021 financial results for Sanofi. Key highlights include:
- Sales grew 2.4% to €8.973 billion, driven by 15% growth in specialty care led by 46% growth of Dupixent to over €1 billion in sales.
- Business EPS grew 9.8% to €1.53, excluding a payment from Daiichi Sankyo.
- Vaccines delivered resilient performance with 5.3% growth, and consumer healthcare also grew.
- The document outlines Sanofi's focus on key areas like immunology, oncology, and expanding access to medicines.
This document provides an overview of Sanofi's Q4 and full year 2020 results. Some key highlights include:
- Q4 sales grew 4.2% driven by strong growth of Dupixent and vaccines. Full year sales grew 3.3%.
- Business operating income margin increased in Q4 and for the full year, trending towards 2022 targets.
- Free cash flow grew significantly to €7 billion in 2020 through business performance, cost savings initiatives, and asset sales.
- A dividend of €3.20 per share is proposed, representing the 27th consecutive year of dividend growth.
Pancreatitis occurs when a patient experiences elevated levels of enzymes in the pancreas. The American Society for Gastrointestinal Endoscopy defines pancreatitis after ERCP as a threefold increase in pancreatic enzymes. This increase is present for more than 24 hours after the procedure.
When Decision-Making Is Imperative: Advance Care Planning for Busy Practice S...VITASAuthor
Complex, chronically ill patients present an opportunity to discuss and implement hospice and palliative care. Many elderly patients who present to the ED and other busy practice settings are hospice-eligible because of functional decline and multi-morbidity. Key tools can quickly facilitate goals-of-care (GOC) conversations, advance care planning, and hospice referrals amid time constraints and high-acuity challenges.
TEST BANK For Radiologic Science for Technologists, 12th Edition by Stewart C...rightmanforbloodline
TEST BANK For Radiologic Science for Technologists, 12th Edition by Stewart C Bushong, Verified Chapters 1 - 40, Complete Newest Version.pdf
TEST BANK For Radiologic Science for Technologists, 12th Edition by Stewart C Bushong, Verified Chapters 1 - 40, Complete Newest Version.pdf
NATURAL, COLORFUL, YUMMY COSMETICS BRAND FOR YOUR BEAUTYzcodebro
Organic Mimi is a real treat for skin and hair care. A healthy and pleasant pampering experience when you want to indulge yourself with organic natural ingredients for skin beauty and delicious fragrances for cheerful mi-mi mood. Our products are "no-fuss": pure formulations and simple application ensure your skin's basic needs for hydration, nourishment and protection are covered. Fun packaging, reminiscent of ice-cream cups, and mimi-aromatherapy turn your everyday skincare routine into a genuine beauty ritual causing beauty addiction
The Best Population Health Management Solutions – Bluestar (2).pptxBluestartelehealth
Are you looking for population health management solutions? Bluestar telehealth offers the best services to support populations & improve outcomes. Learn more!
Benefits:
Stress Relief
Relaxation and rejuvenation of the mind. Stabilizing the nervous system
Maintaining mental clarity and relaxation
Achieving spiritual peace and mental growth.
From the age of about thirteen girls have their periods and they get pain in the lower abdomen. Performing this mudra only for 5-10 minutes relieves the pain.
Scanty or excess bleeding will be regulated.
Practicing this mudra every day for 10 minutes followed by prana mudra will solve the menopause related problems.
As a leading laboratory equipment supplier in India, we have started manufacturing top-class instruments in the fields of biology, life sciences, pharmaceuticals. Labindia Instruments offers the best quality laboratory products and the best after-sales-service.
Our team is empowered to work independently which aids them to ensure complete customer satisfaction. We make sure of an overall growth of our personnel. We equip our team with complete technological expertise so that there is a full technical handholding, enhancing the customer experience and timely support.
Labindia Instruments successfully became the market leaders by providing complete solutions and best quality Instruments from world leaders like Perkin Elmer, Applied Biosyatems, Leica, Koehler, Cannon, Renishaw, Nanonics etc.
In order to ensure complete customer satisfaction, we have established a unified service team. This team compromises of over 30+ service engineers located at different locations all over the country. We aim at strengthening our customer support with this team by excellent manpower with varied skill sets, unmatched expertise and timely aid to the prevailing problems.
Our well-trained, certified technical experts provide service and calibrations for all types of instrumentation.
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Statistics from Finland, provided by the Contact Point for Cross-Border Health Care in Finland and Kela (the Social Insurance Institution of Finland) include information on cross-border healthcare, European Health Insurance Card (EHIC), medical care costs incured abroad and their reimbursements, and prior authorisations for seeking treatment abroad.
The link between skin conditions and mental health issues can be common; problems like dermatitis, acne, and psoriasis often connect with psychological factors. Mind care is crucial for addressing these skin disorders effectively and improving overall well-being.
UNIVERSAL IMMUNIZATION PROGRAMME BY ANUSHRI.pptxAnushriSrivastav
Immunization Programme is the one of the largest programme of world. This programme in India was introduced by WHO in 1978 as Expanded Programme of Immunization (EPI).
In 1985 it was expanded as Universal Immunization Programme that covers all the districts in country by 1989-90 .UIP become a part of CSSM in 1992 and RCH in 1997 and is currently one of the key areas under NRHM since 2005
The action of making a person or animal resistant to a particular infectious disease or pathogens typically by vaccination .
Or
According to WHO – Immunization is the process whereby a person is made immune or resistant to an infectious disease ,typically by the administration of a vaccine
1978: Expanded Programme of immunization (EPI).
Limited reach - mostly urban
1985: Universal Immunization Programme (UIP).
For reduction of mortality and morbidity due to 6 VPD’s.
Indigenous vaccine production capacity enhanced
Cold chain established
Phased implementation - all districts covered by 1989-90.
Monitoring and evaluation system implemented
1986: Technology Mission On Immunization
Monitoring under PMO’s 20 point programme
Coverage in infants (0 – 12 months) monitored
1992: Child Survival and Safe Motherhood (CSSM)
Included both UIP and Safe motherhood program
1997: Reproductive Child Health (RCH 1)
2005: National Rural Health Mission (NRHM)
2012: Government of India declared 2012 as “Year of Intensification of Routine Immunization.
2013: India, along with other South-East Asia Region, declared commitment towards measles elimination and rubella/congenital rubella syndrome (CRS) control by 2020.
2014: No Wild Polio virus case was reported from the country for the last three years and India had a historic achievement and was certified as “polio free country” along with other South East Asia Region (SEAR) countries of WHO.
To reduce morbidity and mortality of the major six childhood disease .
To achieve 100% coverage for eligible children.
To develop a surveillance system .
To minimize the efforts and cost of treatment.
To deliver an integrated immunization services through health centres .
To promote a new healthy generation .
Training of all health personnel .
Strengthening the cold chain .
Promotion of community participation .
Integrate vaccination session with PHC services .
Ensuring regular supply of potent vaccine
Under five year children .
Women in the child bearing age (15-45years).
Schedule of immunization .
Types of the vaccine .
Dose of each vaccines .
Route of administration.
Precautions of vaccinations .
RI targets to vaccinate 27 million new born each year with all primary doses and ~100 million children of 1-5 year age with booster doses of UIP vaccines. In addition, 30 million pregnant mothers are targeted for TT vaccination each year. To vaccinate this cohort of 157 million beneficiaries, ~10 million immunization sessions are conducted, majority of these are at village level
Strategy and policy
Universal Balance Gesture
Benefits:
Your right thumb represents the fire element and the manipura chakra while your little finger is associated with water and the swadhisthana chakra, and your ring finger with the earth element and the muladhara chakra.
Extending these fingers balances your three lower chakras.
1. Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
2. Q3 2023 Results
Play to Win
October 27, 2023
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
3. 3
Forward-looking statements
Investor Relations
This document contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-
looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying
assumptions, statements regarding plans, business transformations, objectives, intentions and expectations with respect to future financial
results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking
statements are generally identified by the words “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans”, “potential”, “outlook”,
“guidance” and similar expressions. Although Sanofi’s management believes that the expectations reflected in such forward-looking statements
are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of
which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially
from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include
among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing,
decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological
application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the
availability or commercial potential of such product candidates, the fact that product candidates if approved may not be commercially successful,
the future approval and commercial success of therapeutic alternatives, Sanofi’s ability to benefit from external growth opportunities, to
complete capital markets or other transactions and/or obtain regulatory clearances, risks associated with developing standalone businesses,
risks associated with intellectual property and any related pending or future litigation and the ultimate outcome of such litigation, trends in
exchange rates and prevailing interest rates, volatile economic and capital market conditions, cost containment initiatives and subsequent
changes thereto, and the impact that pandemics, political disruption or armed conflicts or other global crises may have on us, our customers,
suppliers, vendors, and other business partners, and the financial condition of any one of them, as well as on our employees and on the global
economy as a whole. The risks and uncertainties also include the uncertainties discussed or identified in the public filings with the SEC and the
AMF made by Sanofi, including those listed under “Risk Factors” and “Cautionary Statement Regarding Forward-Looking Statements” in Sanofi’s
annual report on Form 20-F for the year ended December 31, 2022. Other than as required by applicable law, Sanofi does not undertake any
obligation to update or revise any forward-looking information or statements.
Brand names appearing in this presentation are trademarks of Sanofi and/or its affiliates. Not all trademarks related to products under
development have been approved as of the date of this presentation by the relevant health authorities.
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
4. 4
Agenda
Investor Relations
Q3 2023 earnings: Speciality
Care strong growth drives
portfolio transformation
Paul Hudson & Jean-Baptiste de Chatillon
Next chapter of Play to Win
Paul Hudson, Houman Ashrafian
& Julie Van Ongevalle
Financial levers to support
next phase of growth
Paul Hudson & Jean-Baptiste de Chatillon
01
03
02
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
5. 5
Next chapter of Play to Win to drive long-term value
Investor Relations
1. Subject to market conditions and consultations with social partners.
Significantly stepping up
R&D investments
Bolstered by successful
launches and R&D
developments increasing
investments in pipeline
to fully realize long-term
growth potential
Intention to
separate CHC
At the earliest in Q4 2024 via
the creation of a publicly
listed entity headquartered
in Paris1
Enabling management
focus and resource allocation
to the needs of the
Biopharma business
Launch of strategic
cost initiatives
Targeting total up to €2bn
from 2024 to end of 2025,
to be reallocated in majority
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
6. Q3 2023 earnings:
Specialty Care strong
growth drives portfolio
transformation
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
7. 7
Q3 2023: Strong growth of Specialty Care continues to drive
portfolio transformation towards innovative medicines
Investor Relations
All growth at CER unless footnoted. Growth rate is vs. Q3 2022.
Specialty Care
€4.6bn
+13.5%
GenMed
€3.0bn
-6.6%
Vaccines
€3.1bn
-0.6%
Core
assets
€1.5bn
+3.1%
€1.2bn
+4.6%
Consumer
Healthcare
• Q3 sales up 3.2%
• Double-digit growth of Speciality
Care driven by Dupixent and
Rare Diseases
• Vaccines: Beyfortus strong
uptake; Flu sales lower due to
U.S. market dynamics and
delayed shipments in RoW
• CHC growth from key categories
• GenMed core assets up; Non-core
decline due to continued pricing
headwinds
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
8. 8
Significant blockbuster potential with key launches
Investor Relations
Barring unforeseen events. 1. At the end of Q3.
Protect all infants against RSV
in their first season
First and only therapy
to delay onset of T1 diabetes
Potential new standard in
protection with weekly dosing
Q3 execution highlights
~40% share of patient
switches in U.S.1, 650
+ patients on therapy
Strong ramp up in launch
markets U.S., France
and Spain
Growing number of patient
enrollments in the support
programs; 111 patients
infused to date
Combined
sales expectations
raised:
>€500m
in H2 2023
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
9. 9
Dupixent continues impressive growth, annualizing >€11bn
Investor Relations
All growth at CER. 1. Represents growth Q3 2023 to Q3 2022. EADV: European Academy of Dermatology and Venereology.
Global Dupixent sales (€m)
U.S.
(+30%)1
Ex-U.S.
(+43%)1
455
725
1,061
1,803
115
193
349
511
683
Q3 ’19 Q3 ’20 Q3 ’21 Q3 ’22 Q3 ’23
570
918
1,410
2,314
2,847
2,164
750,000
patients
on therapy
globally
U.S. and EU AD
label updated
with adult 5yr
safety data
New
indications to
expand label
Leading
scientific
presence at
EADV
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
10. 6
Influenza leadership driven by differentiated vaccines
in increasingly competitive markets
Investor Relations
Differentiated flu vaccines are Fluzone High Dose/Efluelda and Flublok/Supemtek.
Worldwide differentiated flu vaccines sales
Increased Efluelda penetration
in EU4 markets, with expansion
in additional EU markets
Vaccination coverage rates remain
below pre-pandemic level
Net price erosion on standard
dose vaccine
Key drivers of flu performance
485 392
600
888
49%
Q3
2018
53%
Q3
2019
56%
Q3
2020
66%
Q3
2021
65%
Q3
2022
71%
Q3
2023
1,301 1,249
Sanofi Sales in €m @published rate % of total Sanofi flu sales
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
11. 11
Expanding immunology leadership with differentiated TL1A
candidate in promising class addressing IBD
Investor Relations
The transaction will become effective after customary closing conditions are met. Source: Crohn’s & Colitis Foundation, DRG Clarivate market report (2022), Evaluate Pharma (Q2-2023).
Large underserved market
10m
people WW with IBD
>4m
diagnosed patients
2.7m
treated
patients
>$28bn
2028 WW IBD
Market Sales
Patient population IBD market potential
Potential best-in-class anti-TL1A
profile with differentiated
antibody design
TL1A blockade is an emerging MOA in IBD
and beyond with anti-inflammatory and
anti-fibrotic activity
BIC potential due to greater in vitro potency
and selectivity for DR3 receptor
Favorable safety and tolerability, with
low anti-drug antibody
Collaboration with Teva
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
12. • 10M invasive ExPEC cases worldwide yearly2
• A leading cause of sepsis; high rates of
hospitalizations and mortality3
• Targeting all adults 60+, leveraging our
expertise to gain recommendation and funding
Blockbuster
potential
• Signed agreement with Janssen1
• Worldwide Phase 3 trial ongoing
• Solid addition to Older Adult vaccines portfolio
Strong
portfolio fit
12
First-in-class ExPEC vaccine candidate with excellent strategic fit
Investor Relations
Note: Closing is subject to customary regulatory clearance.
1. Sanofi Press Release 3rd Oct 23. 2. Russo TA and Johnson JR. Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect. 2003;5:449–456.
3. Ohmagari et al., Targeted literature review of the burden of extraintestinal pathogenic Escherichia Coli among elderly patients in Asia Pacific regions. J Med Econ. 2023 Jan-Dec;26(1):168-178.
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
13. 13
Solid financial performance despite Gx impact on Aubagio,
Sanofi’s last meaningful LoE in the decade
Investor Relations
1. Growth rates at CER. 2. At published rates.
13 Investor Relations
9M 2023 9M 2022 Change1
Sales €32.2bn €32.3bn +3.9%
Gross margin 74.8%2 74.3%2 +0.5pts2
R&D spend €4.9bn €4.9bn +1.6%
BOI margin 31.4% 32.0% -0.6pts2
Business EPS €6.45 €6.55 +4.9%
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
14. 14
H2 2023 business outlook
Investor Relations
Barring unforeseen events. 1. ALTUVIIIO, Beyfortus and Tzield. 2. In Other Revenues, booked in Q4.
• Dupixent strong performance to continue
• High rate of Aubagio generic erosion coupled with entry of generics in Europe
• Flu sales split roughly 70/30 Q3 vs. Q4
• GenMed sales decline in the mid-single digit range
• New launches expected to generate sales of >€500m1
Sales
P&L
• Expected COVID vaccine one-off revenues of ~€400m2
• OPEX growth due to investments in launches and R&D; CHC stand-alone
• Capital gains from product divestments expected to reach approximately ~€200m
• Tax rate of 19%
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
15. 15
FY 2023 guidance reaffirmed
Investor Relations
Barring unforeseen events. 1. Based on October 2023 average rates.
15
EPS growth
approximately
-6.0% to -7.0%
Currency
impact1
Mid single-digit
growth at CER
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
16. Next chapter of
Play to Win
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
17. 17
Proof points of success propel next chapter of Play to Win
Investor Relations
Scaling Dupixent
to be among the
world’s leading
medicines
Developing an
industry-leading
immunology
pipeline
Building
a high-growth
vaccines
business
Streamlining
the portfolios
of GenMed
and CHC
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
18. 18
Building on significant progress transforming R&D
over the past 4 years
Investor Relations
6 therapeutic areas
Broad range of
technology platforms
External innovation
International
R&D team
Deploying
AI, data science,
and computational
expertise throughout
the organization
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
19. Orals Injectables
Dermatology
AD IRAK4 degrader amlitelimab (anti-OX40L)
CSU rilzabrutinib (BTKi) Dupixent
HS IRAK4 degrader Anti-TNFa/OX40L Nanobody VHH
Psoriasis Oral TNF inhibitor
Respiratory
Asthma rilzabrutinib (BTKI) amlitelimab (anti-OX40L)
Anti-IL-13/TSLP Nanobody VHH
COPD Dupixent
itepekimab (anti-IL-33)
Gastroenterology
EoE Dupixent (pediatric)
EG Dupixent
UC eclitasertib (RIPK1i) Dupixent
non-beta IL-2 (Synthorin™)
Anti-TL1A mAb
CD Anti-TL1A mAb
Autoimmune
Lupus frexalimab (anti-CD40L)
Anti-CD38 mAb Next Generation
Endocrinology
T1D Tzield
frexalimab
19
Target to expand immunology leadership with new assets
in areas of high unmet need
Investor Relations
Barring unforeseen events. Pipeline table contains assets with indications still under investigation and not yet approved by any regulatory authority.
Leadership today
6m and older
Atopic Dermatitis
Asthma
CRSwNP
EoE
Prurigo Nodularis
Industry leading immunology pipeline
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
20. 20
Amlitelimab shows significant improvements in signs
and symptoms of atopic dermatitis
Investor Relations
1. Data collected after early treatment discontinuation due to reasons other than lack of efficacy prior to endpoint timepoint are included. Data on or after rescue medication or prohibited medications impacting efficacy start date or after the date of treatment
discontinuation due to lack of efficacy prior to endpoint timepoint, were considered as non-responders. Any other unobserved values or other missing data are considered as non-responders at Week 16 and Week 24. 2. All data are used for analysis
regardless of treatment discontinuation, regardless of rescue/prohibited concomitant medications use. Missing data are considered as non-responders at Week 16/Week 24.
0%
10%
20%
30%
40%
50%
60%
70%
40.3
54.5
61.0
11.4
17.7
21.5
Percentage of patients achieving
EASI-75 at Weeks 16 and 24
0%
10%
20%
30%
40%
50%
Percentage of patients achieving
IGA 0/1 at Weeks 16 and 24
Patients
%
22.1
45.5
49.4
5.1
11.4 11.4
250mg
(with LD)
Placebo
Week 161 Week 241 Week 242
Proportion
difference
vs. placebo
(95% CI) p=0.0022
17
(6,27)
p<0.0001
34
(21,47)
p<0.0001
38
(25,51)
Results supporting the potential
for meaningful efficacy in patients with
moderate-to-severe atopic dermatitis
Most rapid and greatest continued
reduction through Week 24 in
Th2/Th17/Th22 biomarkers, suggesting
benefit of loading dose
Opportunity for reducing treatment
dosing frequency
Well-tolerated, with an absence of
fever/pyrexia, chills, and aphthous ulcers
Proportion
difference
vs. placebo
(95% CI)
29
(16,42)
36
(23,50)
39
(25,53)
Patients
%
All p<0.0001
250mg
(with LD)
Placebo
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
21. 21
Avenues of future growth to be presented
at R&D Day on December 7
Investor Relations
Advancing R&D strategic transformation
Sustaining leadership with Dupixent in Type 2
Progressing transformative assets in Immuno-inflammation
and beyond
Leveraging differentiated technology platforms
Employing Artificial Intelligence at scale to accelerate
R&D productivity
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
22. 22
We have built the foundations for CHC’s next phase
of growth as a publicly listed entity
Investor Relations
1. Boehringer Ingelheim. 2. Subject to markets conditions and consultations of social partners.
Today
2014 At the earliest in Q4 20242
2017 2020 end
BU
creation
Publicly
listed
entity
Ready
for next
step
Integration
of B.I.1
Brands
3 strategic
priorities
2023
• €3.3bn net sales
• Below market growth
• Encumbered by Pharma-specific processes
• Decentralized eCommerce & Digital Initiatives
• Inefficiencies due to large portfolio
• €5.2bn net sales
• Proven leadership team
• Brand-led organization
• Established manufacturing footprint
• Clear digital & IT roadmap
• Distinct sustainability commitment
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
23. 23
CHC business reshaped for continued growth
Investor Relations
1. YTD Sep 2023 (excluding Qunol). 2. Excluding Qunol.
15 priority brands All brands with top-3 sales
positions in their respective
geographies, of which 11 are #1
Representing ~2/3
of total net sales1
Representing 85%
of 2019-2022 growth2
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
24. 24
A CHC leader in the attractive OTC & VMS market
Investor Relations
Source: Company reports (OTC & VMS only). Other consumer care (“non-OTC & VMS”) categories include Personal care, Oral Care and Skin Care
OTC & VMS sales
2022, €bn
4.3
0.5
Haleon Kenvue Sanofi CHC Bayer P&G Reckitt Nestlé
4.8
Sanofi CHC
VMS
OTC
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
25. Financial levers
to support next
phase of growth
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
26. 26
Play to Win strategy delivered on financial objectives
Investor Relations
1. 2018 proforma BOI margin of 24.6% without equity investment in Regeneron sold in May 2020, excluding IFRS16 impacts.
Cash flow
30%
BOI margin
10 consecutive quarters of growth
540bps BOI margin improvement
from 2019 to 20221
€2.7bn cost savings re-invested
in growth drivers
>25 value-creating BD and M&A deals
Accelerating digitalization
2020 - 2022
x2
vs. 2018
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
27. 1
27
Capital allocation policy
unchanged
Investor Relations
Organic investment
2 M&A/business development
3 Growing dividend
4 Anti-dilutive share buybacks
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
28. 28
Strengthening the pipeline through increased R&D investment
Investor Relations
2023 numbers will be reported on February 1, 2024. R&D spending 2024E is illustrative.
5.5 5.7
6.7 6.8
2020A 2021A 2022A 2023E 2024E
Continuous growth of absolute R&D spend
from 2020-2023, mainly driven by mRNA
Further increase in 2024 mainly due to
• Frexalimab Phase 3 program in MS
• Phase 3 vaccines programs starting
(PCV, RSV)
• Cost sharing of ExPEC program (JNJ)
• Amlitelimab Phase 3 start moved to 2024
(initially planned for 2023)
Upcoming end of Phase 3 in late 2024
or 2025 (Dupixent and itepekimab
COPD, tolebrutinib)
R&D spend in €bn
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
29. 29
GenMed simplification progressing ahead of plan
Investor Relations
1. 2020 sales excluding third party Industrial Affairs sales.
Streamlining the number of branded product families
~300
2018 2020
H1 2020 YTD Sep
2021
2025E
Long
tail
~220
~180
~160
~100
YTD Sep
2023
~85
Target number of around 100 branded
product families set in 2019 reached two
years earlier than initially planned
Generated more than €1.9 billion of cash
proceeds from divestments 2019 to 2023
Streamlining to continue down to around
85 branded product families
Stabilizing sales in 2025 at the 20201
level no longer an objective
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
30. 30
Launch of strategic cost initiatives, targeting total up to €2bn
from 2024 to end of 2025, to be reallocated in majority
Investor Relations
Priorities
In pursuit of first-in-class/best
in class pipeline assets, active
reallocation of pipeline
resources (i.e., from oncology
to immunology)
Smart
spending
Further leverage
procurement to generate
additional savings
Operational
excellence
Optimize country setup,
increase degree of
centralization by expanding
hub strategy, refocus
R&D infrastructures and
technology platforms
€0.7bn €0.6bn €0.7bn
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
31. +3.9%
31
Preliminary outlook 2024 and 2025
Investor Relations
At CER, barring unforeseen events.
• Continued sales growth supported by
leading franchises and launches
• Dupixent reaching close to €13bn
• Step up in R&D expenses
• Investing behind launches
• Tax rate of 21%
• Low single-digit EPS decline (roughly
stable at comparable tax rate)
Business EPS growth
Company sales growth
• Continued sales growth
supported by Dupixent, other
leading franchises and launches
• Full benefit from planned
efficiency initiatives and
its expectation of relatively
stable R&D expenses and
tax rate year-on-year
• Strong rebound in Business
EPS growth
+4.9%
2024 2025
2020 2022
2021 9M YTD 2023
2020 2022
2021 9M YTD 2023 2024 2025
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
32. 32
Entering the next chapter of our Play to Win strategy
to drive long-term value
Investor Relations
Barring unforeseen events.
32
2020-2022 2023-2024 2025-2030
Consistent capital allocation policy
Refocus with
decisive actions
Growth through
winning assets
Margin expansion
Industry leader in immunology
with >€22bn sales by 2030
Vaccines sales >€10bn by 2030
Ambition to launch 3-5 new products
with €2-5bn peak sales potential each
Stepping up R&D
investment
Aubagio last major LoE,
accelerated GenMed
streamlining
Company
modernization
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
33. Q&A session
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
35. 35
Specialty Care performance
Investor Relations
All growth at CER unless footnoted. Growth rate is vs. Q3 2022.
1. Rare Diseases includes Rare Blood Disorders. 2. Average market share in countries that have launched Nexviazyme as of Aug 23.
Dupixent
€2,847m
+32.8%
Rare Diseases1
€1,284m
+12.1%
€4.6bn sales +13.5%
Neurology,
Oncology &
Rheumatology
€504m
-37.0%
Dupixent
Strong demand-driven growth across all
geographies and approved indications
Rare Diseases
• Nexviazyme average switch rate exceeds 70%2
• Double-digit growth in Fabry franchise, mainly
due to patient accruals
• Hemophilia franchise up in both Hem A and B,
driven by ALTUVIIIO and Alprolix, respectively
• Aubagio LoE sales erosion with full quarter
of U.S. Generics; EU Generics launched
in late Q3
Q3 2023
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
36. Booster
vaccines
€185m
+10.1%
Meningitis
Travel &
Endemic
€409m
-7.6%
36
Vaccines performance
Investor Relations
All growth at CER unless footnoted. Growth rate is vs. Q3 2022.
Polio/Pertussis/Hib
€577m
-3.4%
Influenza
€1,766m
-6.2%
Others
€24m
-10.3%
€3.1bn -0.6%
sales
Outstanding Beyfortus uptake across U.S.,
Spain and France with “All Infant Protection”
programs
Higher sales from differentiated influenza
vaccines, offset by declining vaccination rates,
increased competition in the U.S. and delayed
shipments in RoW
Meningitis franchise sales driven by
CDC order pattern
Beyfortus
€137m
Q3 2023
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
37. Core assets
€1,512m
+3.1%
37
GenMed performance
Investor Relations
All growth at CER unless footnoted. Growth rate is vs. Q3 2022.
€3.0bn -6.6%
sales
Industrial
sales
€126m
+2.4%
Non-core
assets
€1,348m
-16.0%
Core assets
Double-digit growth of Rezurock,
Thymoglobulin and Praluent
Lovenox decline as anticipated; lower
Toujeo sales due to U.S. net pricing
Progressive ramp-up of Tzield
Non-core assets
Lantus impacted by significant U.S. net price
decline due to unfavorable channel mix
Portfolio streamlining
Net Impact on sales: -2.2ppt
Q3 2023
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
38. 38
CHC performance
Investor Relations
All growth at CER. Growth rate is vs. Q3 2022. Organic growth: Excluding impacts of divestments & acquisitions.
€1.2bn sales +4.6%
Physical
& Mental
Wellness
€127m
-4.2%
Others
€173m
-6.5%
Cough & Cold
€131m
+7.9%
Digestive Wellness
€366m
+8.0%
Allergy
€176m
+14.1%
Pain Care
€272m
+5.1%
10th consecutive growth quarter
Growth primarily from price, with volume
maintained at post post-pandemic high base
Digestive Wellness continues to perform
Allergy and Pain Care back to growth, driven by
Allegra worldwide and Eve in Japan, respectively
Q3 organic growth +6.3%
Q3 2023
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
39. Positive drivers of
continued launch execution
90% of U.S. HCPs anticipate
increasing ALTUVIIIO usage
in next 12 months
Permanent J-code available
since October 1, 2023, facilitates
reimbursement
Global expansion with regulatory
approvals in Japan and Taiwan
39
ALTUVIIIO: Best-In-Disease efficacy profile drives strong
Q3 uptake
Investor Relations
1. 2018 proforma BOI margin of 24.6% without equity investment in Regeneron sold in May 2020, excluding IFRS16 impacts.
650+
Patients
with TRx
More than
doubled
total number
of patients
with Rx vs. Q2
#1
Switched
to factor
ALTUVIIIO
captures 40%
of all switches in
hem A market
at the end of Q3
90%
Conversion
rate
% of patients
converting to
commercial
supply post
free trial program
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
40. Record speed to
make Beyfortus
available in the U.S.
• 8 weeks from license
approval to first shipments
in September
• Ad hoc ACIP meeting 3 weeks
post-license with unanimous
vote for All Infant Protection
and VFC inclusion
• Insurance coverage secured
for ~90% of U.S. lives as
of October 1
40
Beyfortus: Unprecedented demand at launch
Investor Relations
Barring unforeseen events.
Rapid adoption immediately
after launch
Launched on September 15
>60% immunization rate
among newborns in hospitals
14 out of 17 regions launched
in the last week of September/
first week of October
>50% immunization rate
of babies in select regions
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
41. 41
GenMed Q3 2023 core assets performance
Investor Relations
All growth at CER unless footnoted.
Core asset sales (in € million)
307 304
230
246
101
83
54
255 265
218
257
93
115
50
-9.8% -4.9%
+5.2%
+12.6%
-1.0% +44.6%
+1.9%
Q3 2022 Q3 2023
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
43. 43
Q3 Group P&L
Investor Relations
All growth at CER. 1. Margin at published rate.
43
Sales growth
+3.2%
Gross margin
-0.6ppt decrease
driven by currency
BOI
-1.0% driven by Aubagio
LoE, unfavorable flu phasing
and unfavorable base of
comparison for the Regeneron
mAbs collaboration
EPS
-2.1% decrease driven
by lower BOI and higher
net financial charges
€m Q3 2023 Q3 2022 % Change
Net Sales 11,964 12,482 +3.2%
Other revenues 734 656 +23.2%
Gross profit 8,858 9,307 +3.5%
Gross margin % 74.0%1 74.6%1
R&D (1,663) (1,736) +0.9%
SG&A (2,579) (2,644) +4.6%
Operating Expenses (4,242) (4,380) +3.1%
Other current operating income & expenses (598) (450) +49.3%
Business Operating Income 4,028 4,498 -1.0%
Business operating margin 33.7%1 36.0%1
Effective tax rate 19% 19%
Total Business Net Income 3,196 3,606 -1.9%
Average number of shares 1,253.2 1,253.5
Business EPS 2.55 2.88 -2.1%
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44. 44
Q3 CHC P&L
Investor Relations
All growth at CER. 1. Margin at published rate.
44
€m Q3 2023 Q3 2022 % Change
Net Sales 1,245 1,300 +4.6%
Other revenues 11 16 -25.0%
Gross profit 754 829 +1.1%
Gross margin % 60.6%1 63.8%1
R&D (52) (54) +1.9%
SG&A (419) (432) +3.2%
Operating Expenses (471) (486) +3.1%
Other current operating income & expenses (3) (4)
Business Operating Income 284 337 +0.9%
Business operating margin 22.8%1 25.9%1
Sales growth
+4.6% driven due to
Digestive Wellness & Allergy
SG&A
+3.2% driven by
investment in stand-alone
organization
BOI margin
reflects Fx impact, lower
gross margin ratio due to
unfavorable mix effect
and inflation impact on
cost of sales
Play to Win Financial levers
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45. 45
9M P&L
Investor Relations
All growth at CER unless footnoted. 1. Margin at published rate.
€m 9M 2023 9M 2022 % Change (CER)
Net Sales 32,151 32,272 +3.9%
Other revenues 2,092 1,661 +32.0%
Gross profit 24,061 23,975 +4.9%
Gross margin % 74.8%1 74.3%1
R&D (4,856) (4,883) +1.6%
SG&A (7,761) (7,597) +5.7%
Operating Expenses (12,617) (12,480) +4.1%
Other current operating income & expenses (1,403) (1,238) +19.5%
Business Operating Income 10,087 10,316 +4.1%
Business operating margin 31.4%1 32.0%1
Effective tax rate 19.0% 19.0%
Total Business Net Income 8,072 8,200 +4.8%
Average number of shares 1,251.0 1,251.2
Business EPS 6.45 6.55 +4.9%
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47. 47 Investor Relations
nirsevimab/Beyfortus
Initial agreement Sanofi-AstraZeneca (March 2017)
Major markets (U.S., FR, DE, ES, IT, UK, JP) Rest of world markets
Net sales Sanofi consolidates worldwide net sales
Cost of sales Sanofi consolidates worldwide cost of sales (finished goods purchased from AstraZeneca)
R&D AstraZeneca & Sanofi share the alliance development costs 50/50
SG&A
Sanofi expenses 100% of its SG&A (and further shares 50/50
in OOIE)
Sanofi expenses 100% of its SG&A
(not shared)
Other operating
income and expenses
Alliance
profit & loss
Sanofi shares with AstraZeneca the alliance commercial
profit & loss 50/50
Sanofi pays to AstraZeneca
25% of net revenues
Intangible asset
Beyfortus
(amortized below
BNI over useful life)
Upfront EUR 120M paid by Sanofi to AstraZeneca upon closing (March 2017)
Regulatory
milestones
AstraZeneca received from Sanofi EUR 55M and will receive EUR 65M for BLA Approval in the U.S.
Sales
milestones
AstraZeneca to receive up to EUR 375M sales milestones from Sanofi, upon achievement of certain sales related milestones
Above BNI Below BNI
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48. 48 Investor Relations
Sanofi accounting of nirsevimab/Beyfortus
Updated and new agreements Sanofi-AstraZeneca and Sanofi-Sobi (October 2023)
U.S. Major markets (CN, FR, DE, ES, IT, UK, JP) Rest of world markets
Net sales Sanofi consolidates worldwide net sales
Cost of sales Sanofi consolidates worldwide cost of sales (finished goods purchased from AstraZeneca)
R&D Sanofi bears 100% of the costs from April 2023 onward AstraZeneca & Sanofi share the alliance development costs
SG&A Sanofi bears 100% of the costs from April 2023 onward Sanofi expenses 100% of its SG&A
(and further shares 50/50 in OOIE)
Sanofi expenses 100% of
its SG&A (not shared)
Other
operating
income and
expenses
Alliance profit
& loss
Sanofi consolidates 100% of the economics in the U.S.
from April 2023 onward
Sanofi shares with AstraZeneca the alliance
commercial profit & loss 50/50
Sanofi pays to AstraZeneca
25% of net revenues
Intangible
asset
Beyfortus
(amortized
below BNI
over useful
life)
Upfront EUR 120M paid by Sanofi to AstraZeneca upon closing (March 2017)
Regulatory milestones AstraZeneca received from Sanofi EUR 120M
Sales milestones AstraZeneca to receive up to EUR 375M sales milestones from Sanofi, upon achievement of certain sales related milestones
Additional rights
from AstraZeneca
(amendment April 2023)
Sanofi records price of U.S rights to obtain full commercial control (Fair Value)
Royalty Agreement Sanofi–Sobi (April 2023)
Financial liability (Sobi) Initial recognition at Fair Value of U.S. royalties due to Sobi - Liability reduced by royalty payments over time -
Subsequent re-measurement in P&L below BNI
Updated agreement Sanofi-AstraZeneca
Above BNI Below BNI
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49. 49 Investor Relations
Q3 sales and EPS
Currency impact
Company sales Business EPS
€661m
€1,108m
€475m
€16m
€-484m
€-922m
+0.12
2022
Q2
+0.31
Q3 Q4
+0.09
Q1
2023
Q2
-0.01
Q3
-0.13
-0.27
2022
Q2 Q3 Q4 Q1
2023
Q2 Q3
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50. 50 Investor Relations
1. Credit ratings reaffirmed: Moody’s A1/stable, S&P AA/stable, Scope AA/stable as of September 30, 2023. 2. Including derivatives used to manage net debt: €142m at December 31, 2022, and €247m at September 30, 2023.
3. Effective January 1, 2019, net debt does not include lease liabilities following the first-time application of IFRS16. 4. Including €363m use of funds from acquisition of treasury shares, -€187m of issuance of Sanofi shares and €577m of other items.
884
3,915
753
6,437
-820
4,454
667
Dividends paid
to shareholders
of Sanofi
10,577
-5,713
Net Debt
December 31,
20222,3
Net Debt
October 27,
20232,3
FCF before
restructuring,
acquisitions
& disposals
Proceeds
from
disposals
Asset
acquisition
Restructuring
& similar
items
Other4
Net debt evolution in 9M 20231
€ millions
Acquisitions of
investments in
consolidated
undertakings
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51. 51 Investor Relations
2023 currency sensitivity and Q3 2023 currency exposure
US $ 48.2%
Euro € 19.7%
Chinese Yuan 5.6%
Japanese Yen 3.1%
Brazilian Real 1.9%
Mexican pesos 1.7%
Canadian $ 1.6%
Turkish Lira 1.4%
Australian $ 1.1%
South Korean won 1.1%
Others 14.6%
Currency exposure on Q3 2023 sales
2023 Business EPS currency sensitivity
Currency Variation Business EPS sensitivity
U.S. Dollar + 0.05 USD/EUR - EUR 0.17
Japanese Yen + 5 JPY/EUR - EUR 0.02
Chinese Yuan + 0.2 CNY/EUR - EUR 0.03
Brazilian Real + 0.4 BRL/EUR - EUR 0.02
Russian Ruble + 10 RUB/EUR - EUR 0.02
Currency average rates
Q3 2022 Q3 2023 % change
EUR/USD 1.007 1.088 +8.1%
EUR/JPY 139.332 157.211 +12.8%
EUR/CNY 6.909 7.896 +14.3%
EUR/BRL 5.289 5.311 +0.4%
EUR/RUB 60.008 102.548 +70.9%
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53. H1 2023 H2 2023
Dupixent
COPD
Positive pivotal trial readout
(BOREAS)
CIndU Efficacy criteria not met
Oncology
Sarclisa (1L MM, IMROZ) Pivotal trial readout (IMROZ)
tusamitamab ravtansine (LC03) Interim analysis
Neurology tolebrutinib Moved to mid-2024 (event-driven)
Rare Blood Disorders
fitusiran (Hem A/B)
Positive pivotal trial readout,
U.S. submission planned in 2024
ALTUVIIIO (Hem A) U.S. approval
Vaccines Beyfortus U.S. approval
53 Investor Relations
As of September 30, 2023, barring unforeseen events. For abbreviations see slide 64.
Major R&D milestones in 2023
ESG appendices Abbreviations Collaborations
R&D appendices
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54. 54 Investor Relations
As of September 30, 2023. For abbreviations see slide 64. For collaborations see slide 65.
R&D Pipeline Phase III & Registration
Name Description Indication
DupixentA
Anti-IL-4/IL-13 mAb Chronic Obstructive Pulmonary Disease
DupixentA Anti-IL-4/IL-13 mAb Bullous Pemphigoid
DupixentA Anti-IL-4/IL-13 mAb Chronic Pruritus of Unknown Origin
itepekimabA Anti-IL-33 mAb Chronic Obstructive Pulmonary Disease
TZIELD Anti-CD3 mAb Type 1 Diabetes
Sarclisa Anti-CD38 mAb + combinations 1L Newly Diag. MM Ti (IMROZ)
Sarclisa Anti-CD38 mAb + combinations 1L Newly Diag. MM Te (GMMG)
Sarclisa Anti-CD38 mAb + combinations Smoldering MM (ITHACA)
Sarclisa Anti-CD38 mAb SubQ. + combinations 2/3L Relapsed, Refractory MM (IRAKLIA)
tusamitamab ravtansine Anti-CEACAM5 ADC 2/3L NSCLC
tolebrutinib BTK inhibitor Relapsing Multiple Sclerosis
tolebrutinib BTK inhibitor Primary Progressive MS
tolebrutinib BTK inhibitor Secondary Progressive MS
Nexviazyme Enzyme Replacement Therapy (GAA) Pompe Disease - Infantile Onset
venglustat Oral GCS inhibitor GM2 Gangliosidosis
venglustat Oral GCS inhibitor Gaucher Disease Type 3
venglustat Oral GCS inhibitor Fabry Disease
fitusiran RNAi targeting anti-thrombin Hemophilia A and B
fitusiran RNAi targeting anti-thrombin Hemophilia A and B pediatric
rilzabrutinib BTK inhibitor Immune Thrombocytopenia
MenQuadfi Meningococcal (A,C,Y,W) conjugate vaccine Meningitis 6w+ (U.S./EU)
VRVg Purified vero rabies Vaccine Rabies
Name Description Indication
DupixentA
Anti-IL-4/IL-13 mAb Chronic Spontaneous Urticaria
Phase III Registration
Immuno-inflammation
Oncology
Neurology
Rare Diseases
Rare Blood Disorders
Vaccines
ESG appendices Abbreviations Collaborations
R&D appendices
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Q3 2023 earnings Financial performance
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55. 55 Investor Relations
As of September 30, 2023. For abbreviations see slide 64. For collaborations see slide 65.
1. Also known as SAR445229. 2. Also known as SAR443122/DNL758. 3. Also known as SAR441344. 4. Also known as KT474. 5. Also known as DNL788. 6. Also known as SP0178. NANOBODY is a trademark of Sanofi and affiliates.
R&D Pipeline – Phase II
Phase II
Name Description Indication
frexalimabC,3
Anti-CD40L mAb Multiple Sclerosis
SAR445088 Complement C1s inhibitor CIDP
SAR443820B,5 RIPK1 inhibitor Amyotrophic Lateral Sclerosis
SAR443820B,5
RIPK1 inhibitor Multiple Sclerosis
rilzabrutinib BTK inhibitor
Warm Autoimmune Hemolytic
Anemia
SAR445088 Complement C1s inhibitor Cold Agglutinin Disease
Fluzone HD6
Inactivated Influenza Vaccine (IIV) Pediatric Influenza
SP0218 Vero cell Vaccine Yellow fever
SP0202D
Next Generation Conjugate Vaccine Pneumococcal
SP0125 Live Attenuated Virus Vaccine RSV toddler
SP0230 Multicomponent Vaccine Meningitis B
Immuno-inflammation
Oncology
Neurology
Rare Diseases
Rare Blood Disorders
Vaccines
R Registrational Study (other than Phase 3)
Name Description Indication
DupixentA
Anti-IL-4/IL-13 mAb Ulcerative Colitis
R KevzaraA Anti-IL-6 mAb
Polyarticular Juvenile Idiopathic
Arthritis
R KevzaraA
Anti-IL-6 mAb Systemic Juvenile Arthritis
amlitelimab1 Anti-OX40L mAb Atopic Dermatitis
amlitelimab1 Anti-OX40L mAb Asthma
rilzabrutinib BTK inhibitor IgG4-related disease
rilzabrutinib BTK inhibitor Asthma
rilzabrutinib BTK inhibitor Chronic Spontaneous Urticaria
eclitasertibB,2 RIPK1 inhibitor Ulcerative Colitis
frexalimabC,3 Anti-CD40L mAb Sjogren’s Syndrome
frexalimabC,3 Anti-CD40L mAb Systemic Lupus Erythematosus
SAR445088 Complement C1s inhibitor Antibody-Mediated Rejection
SAR444656E,4
IRAK4 degrader Hidradenitis Suppurativa
SAR444656E,4 IRAK4 degrader Atopic Dermatitis
SAR442970 Anti-TNFa/OX40L Nanobody VHH® Hidradenitis Suppurativa
Sarclisa Anti-CD38 mAb 1/2L AML/ALL pediatrics
Sarclisa Anti-CD38 mAb + combinations Relapsed, Refractory MM
tusamitamab ravtansine Anti-CEACAM5 ADC + ramucirumab 2/3L NSCLC
tusamitamab ravtansine Anti-CEACAM5 ADC Exploratory Solid tumors
tusamitamab ravtansine Anti-CEACAM5 ADC + pembrolizumab 1L NSCLC
tusamitamab ravtansine Anti-CEACAM5 ADC + ramucirumab Gastric cancer
ESG appendices Abbreviations Collaborations
R&D appendices
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56. 56 Investor Relations
As of September 30, 2023. For abbreviations see slide 64. For collaborations see slide 65.
1. Also known as KDS1001. 2. Also known as KD033. 3. Also known as KD050. 4. Also known as AMX-818. 5. Also known as SAR444245/THOR707. 6. Also known as ABL301. NANOBODY is a trademark of Sanofi and affiliates.
R&D Pipeline – Phase I
Phase I
Name Description Indication
SAR441566 TNFR1 signaling inhibitor Psoriasis
SAR443765 Anti-IL-13/TSLP Nanobody VHH® Asthma
SAR444336 Non-beta IL-2 Synthorin Inflammatory indication
SAR444559 Anti-CD38 mAb Next Generation Inflammatory indication
SAR445611 Anti-CX3CR1 Nanobody VHH® Inflammatory indication
SAR445399 Anti-IL1R3 mAb Inflammatory indication
SAR442257 CD38/CD28/CD3 T-Cell engager MM / N-H Lymphoma
SAR444881F
Anti-ILT2 mAb Solid tumors
SAR4454191 NK-Cell-based immunotherapy Acute Myeloid Leukemia
SAR443216 CD3/CD28/HER2 T-Cell engager Gastric cancer
SAR4457102 Anti-PDL1/IL-15 fusion protein Solid tumors
SAR4458773
Anti-PD1/IL-15 fusion protein Solid tumors
SAR443579G Trifunctional anti-CD123 NK-Cell engager Acute Myeloid Leukemia
SAR445514G Trifunctional anti-BCMA NK-Cell engager Relapsed, Refractory MM
SAR4463094
HER2 T-Cell engager Solid tumors
SAR444200 Anti-GPC3/TCR Nanobody VHH®
Solid tumors
pegenzileukin5 Non-alpha IL-2 Synthorin (dose optimization) Solid tumors
SAR446159H,6 Anti-Synuclein/IGF1R mAb Parkinson’s disease
Name Description Indication
SAR442501 Anti-FGFR3 Ab Achondroplasia
SAR443809 Anti-Factor Bb mAb Rare renal diseases
SAR439459 Anti-TGFb mAb Osteogenesis Imperfecta
SAR444836I
PAH replacement AAV-based gene therapy Phenylketonuria
SP0273 mRNA QIV Influenza
SP0256 mRNA RSV RSV older adults
Immuno-inflammation
Oncology
Neurology
Rare Diseases
Rare Blood Disorders
Vaccines
R Registrational Study (other than Phase 3)
ESG appendices Abbreviations Collaborations
R&D appendices
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57. 2023
KevzaraA
Polyarticular juvenile idiopathic arthritis
2025 and beyond
DupixentA
CPUO
Nexviazyme
Pompe Disease - Infantile Onset
DupixentA
Bullous pemphigoid
venglustat
Gaucher Type 3
KevzaraA
Systemic Juvenile Arthritis
venglustat
Fabry Disease
amlitelimab
Atopic Dermatitis
fitusiran
Hemophilia A/B ped
itepekimabA
COPD
VRVg
Purified vero rabies vaccine
Sarclisa
Smoldering MM
SP0125
RSV toddler
Sarclisa SubQ
3L RR MM (IRAKLIA)
SP0202
Pneumococcal
tolebrutinib
PPMS
SP0218
Yellow fever
frexalimab
MS
57 Investor Relations
As of September 30, 2023. For abbreviations see slide 64. For collaborations see slide 65.
Excluding Phase 1 and 2 (without Proof of Commercial Concept); Projects within a specified year are not arranged by submission timing.
Expected submission timelines
Immuno-inflammation
Oncology
Neurology
Rare Diseases
Rare Blood Disorders
Vaccines
2024
DupixentA
COPD
tolebrutinib
SPMS
Sarclisa
1L Newly Diag. MM Ti (IMROZ)
venglustat
GM2 gangliosidosis
Sarclisa
1L Newly Diag. MM Te (GMMG)
rilzabrutinib
ITP
tusamitamab ravtansine
2/3L NSCLC
fitusiran
Hemophilia A/B
tolebrutinib
RMS
MenQuadfi
6w+
ESG appendices Abbreviations Collaborations
R&D appendices
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59. 59 Investor Relations
Figures presented are YTD.
Sanofi ESG Q3 achievements
Ambition Progress
Q3 2023 Q2 2023
Sanofi
Global Health
Reach 1.5 million NCD patients
by 2026 (cumulative since 2022)
and 2 million by 2030
176,473 patients treated in
27 countries
27 active healthcare partnerships in
14 countries
1 investment
123,025 patients treated
in 24 countries
25 active healthcare
partnerships in 12
countries
1 investment
Vials
donations
Donate 100,000 vials a year to
treat people with rare diseases, via
the Humanitarian Program launched
by Sanofi Specialty Care
1,076 patients treated
74,083 vials donated
1,073 patients treated
52,407 vials donated
Global
access plans
Develop a Global access plan
for all new products to make
them available within two years
after first launch
8 Global Access plans initiated or
developed covering more than 12
indications
6 Global Access plans
initiated or developed
covering more than
10 indications
Affordable access
ESG appendices Abbreviations Collaborations
R&D appendices
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60. 60 Investor Relations
Figures presented are YTD.
Sanofi ESG Q3 achievements
Ambition Progress
Q3 2023 Q2 2023
Sleeping
sickness
Develop and supply innovative
treatments to support the
elimination of sleeping sickness
by 2030
Data updated annually, next update
in Q2 2024
1.5 million
patients tested in 2022
837 patients treated
in 2022
Polio Provide inactivated polio vaccines
(IPV) to UNICEF for GAVI countries
to support polio eradication efforts
23.7 million IPV doses supplied
to UNICEF for GAVI countries
18.8 million IPV doses
supplied to UNICEF for
GAVI countries
Pediatric cancer
treatment
development
Develop innovative treatments to
eliminate cancer death in children
2 assets in protocol preparation
for clinical study
2 external collaboration
contracts with the pediatric ITCC
consortium established
2 assets in protocol
preparation for
clinical study
2 external collaboration
contracts with the
pediatric ITCC consortium
established
R&D for unmet needs
ESG appendices Abbreviations Collaborations
R&D appendices
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61. 61 Investor Relations
Figures presented are YTD.
Sanofi ESG Q3 achievements
Ambition Progress
Q3 2023 Q2 2023
Climate change -
carbon footprint
CO2 emissions
55% reduction in scope 1&2
greenhouse gas emissions (CO2
equivalent) by 2030 (cumulative
vs. 2019 baseline) to contribute to
carbon neutrality by 2030 and net
zero emissions by 2045 (all scopes)
35.0% GHG reduction
vs 2019
32.6% GHG
reduction vs. 2019
Renewable
electricity
100% of renewable electricity
in all our sites by 2030
72.0% 67.2%
Eco-car
fleet
100% carbon neutral
car fleet in 2030
39.8% eco fleet 36.5% eco fleet
Blister free syringe
vaccines
100% blister free syringe vaccines
by 2027(updated annually)
Data updated annually, next update
in Q4 2023
33% of blister free
syringe produced in 2022
Eco-design All new products to be
eco-designed by 2025
8 LCAs completed &
7 in progress (new and
marketed products)
7 LCAs completed &
4 in progress (new and
marketed products)
Planet Care
ESG appendices Abbreviations Collaborations
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62. 62 Investor Relations
Figures presented are YTD.
Sanofi ESG Q3 achievements
Ambition Progress
Q3 2023 Q2 2023
Gender
balance
Ambition of 50% of women in
senior leaders by 2025
43.3% 42.4%
Ambition of 40% of women in
executive posts by 2025
39.3% 38.0%
Engagement with
communities
Engage socially and economically
with all communities where we
operate
5,905 volunteers
36,746 hours
2,883 volunteers
18,103 hours
From Leaders
to Citizens
100% of Sanofi leaders have
CSR in their development path
69% of the leaders have
completed the eLearning phase
18% of the leaders have
completed the full program
68% of the leaders
have completed the
eLearning phase
12% of the leaders
have completed the
full program
In and beyond the workplace
ESG appendices Abbreviations Collaborations
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63. 63 Investor Relations
Scores assigned by the rating agencies are not equivalent.
Sanofi ESG ratings
Rating agencies
SCORE
87/100
21.5
Medium risk
78/100 A
Climate
Change: A
Water: A-
B 4.5/5 3.47/5 65/100
86/100 21.2 71/100 A A/A B 4.3/5 3.47/5 64/100
One of the highest
scores across all
sectors globally
81 points for its
solid fundamentals
& strong
preparedness
opinion of
6 points
17th among 419
pharmaceutical
companies
Percentile of 98
within 344 scored
companies in the
industry
Score stable
since 2021
Leading position 1st decile of the
476 companies in
the industry
With very high
rating across the
3 pillars ESG
Top 10
company
1st pharmaceutical
company out of 57
Score improving
since 2018
vs. previous rating
ESG appendices Abbreviations Collaborations
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64. 64 Investor Relations
Abbreviations
AAV Adeno-Associated Virus
Ab Antibody
AD Atopic Dermatitis
ADC Antibody Drug Conjugate
ALL Acute Lymphoblastic Leukemia
AML Acute Myeloid Leukemia
BCMA B-Cell Maturation Antigen
BTK Bruton’s Tyrosine Kinase
CD Cluster of Differentiation
CD Crohn’s Disease
CEACAM5 Carcinoembryonic Antigen Cell Adhesion
Molecule 5
CI Confidence Interval
CIDP Chronic Inflammatory Demyelinating
Polyneuropathy
CInDU Chronic Inducible Cold Urticaria
COPD Chronic Obstructive Pulmonary Disease
CPUO Chronic Pruritus of Unknown Origin
CSR Corporate Social Responsibility
CSU Chronic Spontaneous Urticaria
DR3 Death Receptor 3
EASI Eczema Area and Severity Index
EG Eosinophilic Gastritis
EoE Eosinophilic Esophagitis
ExPEC Extraintestinal pathogenic E. coli
FGFR3 Fibroblast Growth Factor Receptor 3
GAA Acid Alpha-Glucosidase
GCS Glucosylceramide Synthase
GHG Greenhouse Gas
GPC3 Glypican-3
HD High Dose
HS Hidradenitis Suppurativa
HER2 Human Epidermal growth factor Receptor 2
IA Interim analysis
IBD Inflammatory Bowel Disease
IED Invasive ExPEC Disease
IGA Investigator Global Assessment
IGF1R Insulin Like Growth Factor 1 Receptor
IL Interleukin
ILT2 Ig-like transcript 2
IPV Inactivated Poliomyelitis Vaccine
IRAK4 Interleukin 1 Receptor Associated Kinase 4
ITCC Innovative Therapies for Children
with Cancer
ITP Immune Thrombocytopenia
LCA Life Cycle Assessment
LD Loading Dose
LoE Loss of Exclusivity
LRTD Lower Respiratory Tract Diseases
mAb monoclonal Antibody
MM Multiple Myeloma
mRNA messenger RNA
MS Multiple Sclerosis
NCD Non-Communicable Diseases
NGO Non-Governmental Organizations
N-H Non-Hodgkin
NK Natural Killer
NSCLC Non-Small Cell Lung Cancer
PAH Phenylalanine Hydroxylase
PD-1 Programmed Death protein 1
PD-L1 Programmed Death ligand 1
PN Prurigo Nodularis
PPMS Primary Progressive Multiple Sclerosis
PP-NRS Peak-Pruritus Numerical Rating Scale
QIV Quadrivalent Influenza Vaccine
RIPK1 Receptor-Interacting serine/threonine-
Protein Kinase 1
RMS Relapsing Multiple Sclerosis
RNAi RNA interference
RRMM Relapsed-Refractory Multiple Myeloma
RSV Respiratory Syncytial Virus
SPMS Secondary-Progressive Multiple Sclerosis
TCR T Cell Receptor
Te Transplant eligible
TGFb Transforming Growth Factor beta
Th Helper T-Cell
Ti Transplant ineligible
TL1A TNF-like Ligand 1A
TNF Tumor Necrosis Factor
TSLP Thymic Stromal Lymphopoietin
T1D Type 1 Diabetes
UC Ulcerative Colitis
VBP Volume-based Procurement
VFC Vaccines for Children
ESG appendices Abbreviations Collaborations
R&D appendices
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
65. 65 Investor Relations
Collaborations
Ref Name Developed in collaboration with…
A Dupixent
itepekimab
Kevzara
Regeneron
B eclitasertib
SAR443820
Denali
C frexalimab ImmuNext
D SP0202 SK
E SAR444656 Kymera
F SAR444881 Biond Biologics
G SAR443579
SAR445514
Innate Pharma
H SAR446159 ABL Bio
I SAR444836 Medicinova, Inc
TEV’574 Teva Pharmaceuticals
ExPEC9V Vaccine Janssen Pharmaceuticals, Inc., a Johnson & Johnson company
ESG appendices Abbreviations Collaborations
R&D appendices
Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices
66. Play to Win Financial levers
Q3 2023 earnings Financial performance
Business update Appendices