This document provides an agenda and summaries for Sanofi's Q4 2023 results presentation. The agenda includes sections on R&D update, Biopharma update, Consumer Healthcare update, Growth engine outlook for 2024, and Financial performance. Some key highlights include:
- Specialty Care and Vaccines drove strong growth, with Dupixent sales adding €2.8 billion.
- 2023 launches exceeded sales expectations, bringing in over €2.2 billion combined.
- The pipeline has numerous expected milestones in 2024, including Dupixent COPD approval and results from multiple Phase 2 and 3 trials.
- An acquisition of INBRX-101 was announced to add an innovative asset for
The document analyzes trends in the global mobile gaming market in 2022. It finds that the Hypercasual genre, which had seen huge growth during the pandemic, declined substantially in 2022. However, the new Hybridcasual model, which combines elements of casual, hypercasual, and mid-core games, saw significant download growth as many developers transitioned to this approach. The document also examines revenue trends for different genres, finding declines in most top genres except for Action and Tabletop games.
Riot Games Interview presentation Product launch planEdward Hwang
Though I failed to get the job as a product manager for SEA region after more than 10 interviews and hundreds of e-mails exchanged over a 6 months period, I still would like to share this slide that helped me get to the very last stage of the interview.
I made the slide within a week between interviews based on the request of the hiring manager to come up with a hypothetically scenario to launch a new product for Riot Games. The idea was to basically understand your skill-set and thinking process. And, of course to have something more solid to initiate a better communication during the interview process.
Anyways, I hope this helps if anyone is interviewing for a similar gaming company.
Newzoo games esports_cloud_metaverse_trends_2022digitalinasia
The document discusses several topics related to games, esports, live streaming, cloud gaming and the metaverse. Some key points:
1. NFT games currently face challenges like bans on some platforms and player backlash, but publishers are exploring ways to legitimize player-to-player trading and monetization.
2. The metaverse envisioned by companies like Meta and Microsoft won't be fully realized for years, but interest is growing, driven by VR headset launches and investment in emerging technologies.
3. Major game releases in 2022 and ongoing chip shortages may positively impact cloud gaming adoption as the cloud allows players to experience new titles without hard-to-find hardware.
Vietnam Mobile Marketing and Game 2019 (English new)Appota Group
This document provides an overview and analysis of the mobile marketing and gaming market in Vietnam. Some key points:
- Mobile gaming has 33 million players in Vietnam currently and is projected to reach 40 million by 2020. Nearly half of mobile internet users play games on their phones.
- The top apps and games in Vietnam are mainly social networking apps and online esports games. Popular titles include Arena of Valor, Candy Crush Saga, and Clash of Clans.
- Mobile advertising spending in Vietnam grew rapidly in 2018 and accounted for 62% of total digital ad spending. Social media receives the largest portion of digital ad budgets. Video advertising is forecasted to have the highest growth rate.
- The
This document is Mondelēz International's 2021 ESG Report which summarizes the company's environmental, social and governance priorities and progress. It discusses Mondelēz's purpose of empowering people to snack right through offering the right snack made the right way. The report provides an overview of Mondelēz's ESG strategy, goals and initiatives in areas such as sustainable sourcing, climate action, packaging, social impact and diversity. It also highlights accomplishments in 2021, including setting a goal to achieve net zero emissions by 2050 and advancing diversity, equity and inclusion.
The document proposes a blockchain-based gaming ecosystem called Joy Gaming that aims to decentralize the online casino market. It seeks to address issues like market monopolization, limited innovation due to high development costs, and lack of trust in game results. The ecosystem would utilize smart contracts to guarantee and record transactions transparently on the blockchain to engrain trust. It would incentivize developers to create new content and enhance the user experience. This is expected to attract more players, developers and reduce infrastructure costs for casinos.
This publication serves as the first in-depth DMCC (Dubai Multi Commodities Centre) thought leadership report on the global and local gaming and esports ecosystem. It gathers contributions from key opinion leaders to share their views on where the gaming and esports industry is heading and places emphasis on the drivers of gaming and esports from a technology, culture and business perspective.
This document provides a summary of a presentation given by Antonio Achille of BCG Milan on insights from a global luxury consumer research study. The study interviewed 10,000 luxury consumers across 10 countries on their consumption behaviors.
The presentation addressed six questions: why focus on luxury consumers now, what makes the study unique, what is needed to drive growth in key categories, where future growth will come from, which consumer segments will drive growth, and trends shaping the industry. Key findings included that organic growth from existing markets will be the main driver of growth, US consumers will be the largest contributor, and digital influence on purchases is increasing significantly year-over-year.
The document discusses go-to-market strategies for startups. It provides a framework for marketing and sales cycles including strategies around awareness, interest, understanding, engagement, trial and purchase. It also discusses branding, positioning, targeting and segmentation. The document emphasizes the importance of consistency in branding from the start and focusing the value proposition on the needs of a target customer segment. It introduces concepts like minimum viable product and minimum viable segment.
The CMO Survey - Highlights and Insights Report - Fall 2023christinemoorman
Despite renewed optimism about the economy, marketing budgets as a percentage of overall company budgets and revenues dropped to near pre-Covid levels of 10.6% and 9.2% respectively. Growth in marketing spending and digital marketing spending also decreased substantially from prior periods. Inflationary pressures may be impacting marketing investment, though the impact is lessening. Spending on customer experience is predicted to increase in the next 12 months, while spending on brands, customer relationships and new products is expected to slow. Traditional advertising spending growth turned positive but remained low. Marketing budgets vary significantly by firm size and industry.
The document discusses the games industry and the major players within it, including console manufacturers Nintendo, Sony, and Microsoft, as well as publishers and developers. It covers Nintendo's focus on innovation and accessibility with the Wii, Sony and Microsoft's focus on graphical power and online experiences with the PlayStation 3 and Xbox 360, and the strategies of maintaining existing markets while expanding to new audiences.
The document provides an overview of Sanofi's Q4 and full year 2021 results. Key highlights include:
- Global sales grew 7.1% in 2021 to €37.7 billion, driven by strong growth of Specialty Care which became the largest business unit.
- Dupixent sales increased 53% in Q4 to €1.55 billion, with growth across all regions. Prurigo nodularis phase 3 trials showed significant improvements.
- Vaccines sales declined 6.5% in Q4 due to earlier seasonal flu shipments, while full year flu vaccine sales reached record levels in 2021.
- Planned launches of sutimlimab for CAD in 2022 and olp
Sanofi reported strong Q2 2022 results, with Dupixent sales nearly reaching €2 billion. Dupixent continues its outstanding performance with 43.4% sales growth year-over-year, driven by new indications and approvals in both the US and EU. Sanofi's pipeline is advancing with regulatory submissions for efanesoctocog alfa and nirsevimab expected in 2022. Positive data was also reported for the company's Beta-containing COVID-19 vaccine against variants including Omicron.
Sanofi reported Q3 2022 results with sales growing 9.0% driven by strong performances from Specialty Care and Vaccines. Dupixent sales grew 44.5% from new launches in indications like EoE and younger populations. Vaccines sales increased 23.5% on growth of flu vaccines and recovery of travel vaccines. The document notes several forward-looking statements and risks that could impact projections. Upcoming newsflow over the next 18 months includes data readouts from late-stage trials in areas like oncology, immunology, and vaccines.
- Amlitelimab, an investigational IRAK4 degrader, showed significant improvements in signs and symptoms of atopic dermatitis in a Phase 2b trial. At week 16, 40.3% of patients achieved EASI-75 with amlitelimab vs 11.4% with placebo, and 22.1% achieved IGA 0/1 vs 5.1% with placebo.
- At week 24, amlitelimab continued to show benefits over placebo with 54.5% achieving EASI-75 vs 17.7% for placebo, and 45.5% achieving IGA 0/1 vs 11.4% for placebo.
- Amlitelimab
Sanofi reported its Q4 and full year 2022 results with strong growth. The document discusses Sanofi's strategy execution which delivered growth and margin expansion through 2022. It provides an agenda for the investor relations presentation covering a business update on specialty care, vaccines, GenMed and consumer healthcare performance in Q4 2022 as well as the financial performance and outlook for 2023.
The document provides an update on Sanofi's Q1 2023 results and outlook. It discusses strong growth in Specialty Care driven by Dupixent and vaccines. Dupixent sales grew 40% in Q1 supported by new indications. Positive Phase 3 data was announced for Dupixent in COPD. The pipeline includes 12 novel molecules in immunology. Tofezimbab is progressing in multiple sclerosis trials. The document outlines the strategy to leverage innovation and drive growth to 2030.
The document summarizes Q1 2021 financial results for Sanofi. Key highlights include:
- Sales grew 2.4% to €8.973 billion, driven by 15% growth in specialty care led by 46% growth of Dupixent to over €1 billion in sales.
- Business EPS grew 9.8% to €1.53, excluding a payment from Daiichi Sankyo.
- Vaccines delivered resilient performance with 5.3% growth, and consumer healthcare also grew.
- The document outlines Sanofi's focus on key areas like immunology, oncology, and expanding access to medicines.
- Q1 2020 sales were €8.973 billion, up 6.6% driven by strong Dupixent sales growth.
- Dupixent sales increased 130% to €776 million and continue to see double-digit growth.
- Specialty Care sales were up 31.3% led by Dupixent while General Medicines sales fell 3.8% due to COVID-19 stocking and China's VBP program.
- Sanofi reported Q3 2020 results with total sales of €9.5 billion, up 5.7% year-over-year at CER.
- Dupixent sales grew 69% to €918 million driven by strong performance in atopic dermatitis and asthma.
- Vaccines sales increased 14% to €2.1 billion due to a record flu season with over 80 million doses delivered in the US.
- General Medicines sales declined 7% to €3.6 billion due to anticipated price impacts in China, while Diabetes sales declined by low single digits globally.
This document provides a summary of Sanofi's Q4 and full year 2019 results. It includes sections on business updates from the CEO, R&D updates, and financial updates. Some key highlights include Dupixent sales reaching €2.1 billion in 2019, pipeline progress such as positive proof-of-concept data for BTKi in multiple sclerosis, and full year sales growing 2.8% to €36 billion. The document also outlines priorities for 2020 such as expanding Dupixent indications and influenza vaccine differentiation in the US.
- Sanofi reported Q2 2019 results with sales of €8.6 billion, up 4.8% year-over-year at CER. Business EPS was €1.31, up 3.9% at CER.
- Specialty care sales grew strongly at 22.1% driven by Dupixent. Vaccines sales increased 24.7% led by Pentaxim in China and boosters. Primary care sales declined 10.4% due to pricing pressures and LoEs in diabetes and established products.
- Emerging markets sales increased 10% with double digit growth in Asia and Latin America led by specialty care and vaccines portfolio shift. China sales grew 17.1% to €709 million
This document provides an overview of Sanofi's Q4 and full year 2020 results. Some key highlights include:
- Q4 sales grew 4.2% driven by strong growth of Dupixent and vaccines. Full year sales grew 3.3%.
- Business operating income margin increased in Q4 and for the full year, trending towards 2022 targets.
- Free cash flow grew significantly to €7 billion in 2020 through business performance, cost savings initiatives, and asset sales.
- A dividend of €3.20 per share is proposed, representing the 27th consecutive year of dividend growth.
- Sanofi reported Q1 2022 results with sales growth of 8.6% and earnings per share growth of 16.1%.
- Dupixent sales increased 45.7% driven by strong performance across indications.
- Vaccines sales grew 6.8% led by pertussis-containing vaccines in China and higher sales of travel and endemic vaccines.
- The company advanced its pipeline during the quarter with regulatory submissions and trials across core therapeutic areas.
- Sanofi reported Q2 2023 results with total sales up 3.3% driven by double-digit growth of Specialty Care led by Dupixent and strong growth in Vaccines, while CHC was impacted by a Q1 inventory build.
- Specialty Care sales increased 11.8% led by 34.2% growth of Dupixent which saw demand-driven growth across its five approved indications. Rare Diseases grew 9.6% mainly due to patient accruals in Fabry and Pompe franchises and the strong launch of Nexviazyme. Neurology, Oncology and Rheumatology declined 35.1% due to LOE impact on Aubagio.
-
- Frexalimab demonstrated significantly reduced disease activity in relapsing multiple sclerosis in a phase 2 trial, meeting its primary endpoint with an 89% reduction in new gadolinium-enhancing lesions. It was well tolerated across all dose arms. Pivotal trials are planned to start in 2024.
- Amlitelimab showed statistically significant improvements in atopic dermatitis symptoms compared to placebo in a phase 2b trial. Biomarker results support effects on both type 2 and non-type 2 inflammation pathways. It was well tolerated. Pivotal trials are planned for 2024.
- A phase 1b trial of SAR443765, an IL-13/TSL
- Sanofi reported Q4 and full year 2017 results on February 7, 2018.
- For full year 2017, company sales grew 0.5% to €35.1 billion despite losses of exclusivity, in line with expectations. Business EPS was broadly stable at €5.54.
- In Q4 2017, company sales declined 1.6% to €8.7 billion due to declines in Diabetes & Cardiovascular and GEM, partially offset by growth in Specialty Care and Vaccines.
- The document discusses forward-looking statements and contains projections and estimates about Sanofi's future performance that may not come to pass.
- It provides an agenda for a presentation covering key highlights, financial performance, and a Q&A session.
- The presentation will include remarks from Sanofi's CEO and CFO as well as several other executive vice presidents.
Merck reported strong financial results for fiscal year 2016. Net sales increased 17% to €15.02 billion, driven by organic growth across all regions and the acquisition of Sigma-Aldrich. EBITDA pre increased 24% to €4.49 billion and EPS pre increased 28% to €6.21, both exceeding guidance. All business sectors achieved organic growth, with particularly strong contributions from the Life Science and Healthcare sectors. Merck also reduced net financial debt by 9% and proposed a dividend of €1.20 per share, a 19% increase over the prior year.
Johnson & Johnson Pharmaceutical Business ReviewDeepa K
The document is an agenda for an investor presentation. It outlines the schedule for the day which includes presentations on the company's enterprise overview, pharmaceutical commercial and R&D strategies, and various therapeutic areas. It also includes notices about forward-looking statements and new molecular entities being discussed. The speakers and locations are listed next to each topic.
- Q3 2017 company sales grew 4.7% at CER to €9.1 billion, driven by specialty care and vaccines franchises. Diabetes sales declined 14.8% due to losses of exclusivity.
- Specialty care grew 13.9% led by strong Dupixent sales in the US and Kevzara gaining 15% of the IL-6 market share. Vaccines grew 7.2% with strong pediatric combination vaccine sales.
- Consumer healthcare grew 1% with emerging markets up 6.7% offsetting declines in developed markets due to increased competition.
Similar to Fourth quarter and full year 2023 results (20)
Sanofi reported solid financial results for Q2 2023, with sales increasing 3.3% to €9,965 million and business earnings per share growing 8.1% to €1.74. By business unit, Specialty Care saw the highest sales of €4,403 million, followed by General Medicines at €3,114 million and Vaccines at €1,223 million. Geographically, the United States was the largest market with sales of €3,919 million. Sanofi also highlighted several positive clinical trial readouts, including FDA approval of their RSV prevention treatment for newborns and infants, positive phase 3 data for a COPD biologic, and positive phase 2b results for
Sanofi reported strong Q1 2023 results, with specialty care sales up 18.3% driven by Dupixent growth of 39.7%. Vaccines sales also grew 15.2% from COVID contracts and travel vaccine recovery. R&D updates included positive Dupixent COPD data and promising early immunology assets. The document provided financial and business performance summaries for Q1 2023 and outlook.
Sanofi reported strong Q1 2023 results, with sales growth of 5.5% overall. The Specialty Care unit grew 18.3% driven by Dupixent sales increasing 39.7%. Dupixent continues to see strong demand globally. Vaccines sales grew 15.2% from COVID contracts and travel/booster vaccine recovery. R&D advancements included positive Dupixent COPD data and upcoming events for fitusiran and tolebrutinib. Financial guidance and outlook will be provided later in the year.
Sanofi reported strong financial results for 2022, with company sales growing 7.0% to €42,997 million and business EPS increasing 17.1% to €8.26. The company will continue investing in science as it launches the next phase of its strategy to maintain progress developing first and best in class medicines. Recent regulatory approvals in Europe include treatments for prurigo nodularis, a COVID-19 booster vaccine, prevention of respiratory syncytial virus in infants, and cold agglutinin disease.
Sanofi delivered strong third quarter results with sales growth of 9.0% and business EPS growth of 17.9%. The company achieved key regulatory milestones for three of its priority medicines and its commitment to breakthrough science is bearing fruit. Paul Hudson, Chief Executive Officer, noted that the results demonstrate Sanofi is on the right path.
Sanofi reported €9,674 million in company sales for Q1 2022, an increase of 8.6% at constant exchange rates. The company's CEO noted they made progress in immunology with 13 potential new treatments in development. Specialty Care was Sanofi's largest global business unit by sales in Q1 2022, generating €3,566 million, followed by General Medicines with €3,760 million.
Sanofi reported its Q4 and full year 2021 results. The document contains forward-looking statements and discusses Sanofi's Q4 performance, pipeline progress, and planned upcoming launches. Key highlights include Specialty Care becoming Sanofi's largest business unit driven by strong Dupixent sales of €1.5 billion in Q4. The pipeline was also strengthened with the addition of 36 projects in phase I/II.
Presentation Part 2 – Leading with innovationSanofi
Sanofi is building an innovative and diversified vaccine pipeline by expanding into new disease areas and technologies. They have added mRNA and LNP platforms and have 10 new development candidates by 2025, including 6 mRNA vaccines. Sanofi is focusing on first-in-class or best-in-class vaccines and leveraging immunology, antigen design, and the best technology for each target. They are broadening their pipeline to address additional chronic diseases and expanding populations.
Presentation Part 1 – Growing current business Sanofi
Sanofi is focused on growing its vaccines business by winning in influenza, launching nirsevimab to protect all infants against RSV, and unlocking the potential of mRNA technology. The company aims to more than double its vaccines sales by the end of the decade through continued expansion of existing franchises like influenza, entry into new areas like pneumococcal vaccines, and delivery of new mRNA vaccine candidates. Sanofi believes it has the capabilities needed to succeed, including best-in-class vaccines, large-scale manufacturing and supply expertise, and a strengthening pipeline.
Play to Win is Sanofi's Q3 2021 results document. It summarizes strong sales and earnings growth in Q3 2021 driven by 10% sales growth and 19% growth in business EPS. Key drivers included a 55% increase in Dupixent sales to €1.41 billion. Vaccines also saw record sales. Sanofi raised its full-year 2021 business EPS growth guidance to 14% due to the outstanding quarterly performance. The document discusses Sanofi's strategy of pursuing bolt-on acquisitions to strengthen key areas and pipeline progress, and provides an overview of segment performance in Q3.
Play to Win Q2 2021 Results
- Sanofi reported sales of €8.7 billion in Q2 2021, up 12% year-over-year, and business EPS of €1.38, up 16% year-over-year.
- Dupixent sales grew 57% year-over-year to €1.2 billion, driven by strong performance in both the US and ex-US markets.
- Vaccines sales increased by double digits to €1 billion in Q2 2021 compared to the same period in 2020.
- The presentation reviewed Sanofi's progress on priority R&D assets and initiatives to increase diversity and inclusion in the workplace.
Sanofi reported its Q2 2020 results, highlighting a 9.2% increase in EPS driven by strong Dupixent sales growth of 94%. While most business units saw impacts from COVID-19, Dupixent maintained momentum with new launches and indications. Sanofi also progressed its pipeline including initiating Phase 3 for BTK inhibitor '168 in multiple sclerosis.
This document contains forward-looking statements regarding Sanofi's strategic outlook, key growth drivers, and pipeline of potential transformative therapies. It discusses the significant growth potential of Dupixent across type 2 inflammatory diseases, with an ambition to achieve over €10 billion in peak sales. Vaccines are also highlighted as an expected mid-to-high single-digit growth driver through 2025. The pipeline includes potential first-in-class or best-in-class therapies for diseases like multiple sclerosis, respiratory syncytial virus, and breast cancer that could transform patient care if approved.
Solution Manual For Fundamentals of Financial Accounting, 8th Edition 2024 by...rightmanforbloodline
Solution Manual For Fundamentals of Financial Accounting, 8th Edition 2024 by Fred Phillips.pdf
Solution Manual For Fundamentals of Financial Accounting, 8th Edition 2024 by Fred Phillips.pdf
Pancreatitis occurs when a patient experiences elevated levels of enzymes in the pancreas. The American Society for Gastrointestinal Endoscopy defines pancreatitis after ERCP as a threefold increase in pancreatic enzymes. This increase is present for more than 24 hours after the procedure.
UNIVERSAL IMMUNIZATION PROGRAMME BY ANUSHRI.pptxAnushriSrivastav
Immunization Programme is the one of the largest programme of world. This programme in India was introduced by WHO in 1978 as Expanded Programme of Immunization (EPI).
In 1985 it was expanded as Universal Immunization Programme that covers all the districts in country by 1989-90 .UIP become a part of CSSM in 1992 and RCH in 1997 and is currently one of the key areas under NRHM since 2005
The action of making a person or animal resistant to a particular infectious disease or pathogens typically by vaccination .
Or
According to WHO – Immunization is the process whereby a person is made immune or resistant to an infectious disease ,typically by the administration of a vaccine
1978: Expanded Programme of immunization (EPI).
Limited reach - mostly urban
1985: Universal Immunization Programme (UIP).
For reduction of mortality and morbidity due to 6 VPD’s.
Indigenous vaccine production capacity enhanced
Cold chain established
Phased implementation - all districts covered by 1989-90.
Monitoring and evaluation system implemented
1986: Technology Mission On Immunization
Monitoring under PMO’s 20 point programme
Coverage in infants (0 – 12 months) monitored
1992: Child Survival and Safe Motherhood (CSSM)
Included both UIP and Safe motherhood program
1997: Reproductive Child Health (RCH 1)
2005: National Rural Health Mission (NRHM)
2012: Government of India declared 2012 as “Year of Intensification of Routine Immunization.
2013: India, along with other South-East Asia Region, declared commitment towards measles elimination and rubella/congenital rubella syndrome (CRS) control by 2020.
2014: No Wild Polio virus case was reported from the country for the last three years and India had a historic achievement and was certified as “polio free country” along with other South East Asia Region (SEAR) countries of WHO.
To reduce morbidity and mortality of the major six childhood disease .
To achieve 100% coverage for eligible children.
To develop a surveillance system .
To minimize the efforts and cost of treatment.
To deliver an integrated immunization services through health centres .
To promote a new healthy generation .
Training of all health personnel .
Strengthening the cold chain .
Promotion of community participation .
Integrate vaccination session with PHC services .
Ensuring regular supply of potent vaccine
Under five year children .
Women in the child bearing age (15-45years).
Schedule of immunization .
Types of the vaccine .
Dose of each vaccines .
Route of administration.
Precautions of vaccinations .
RI targets to vaccinate 27 million new born each year with all primary doses and ~100 million children of 1-5 year age with booster doses of UIP vaccines. In addition, 30 million pregnant mothers are targeted for TT vaccination each year. To vaccinate this cohort of 157 million beneficiaries, ~10 million immunization sessions are conducted, majority of these are at village level
Strategy and policy
When Decision-Making Is Imperative: Advance Care Planning for Busy Practice S...VITASAuthor
Complex, chronically ill patients present an opportunity to discuss and implement hospice and palliative care. Many elderly patients who present to the ED and other busy practice settings are hospice-eligible because of functional decline and multi-morbidity. Key tools can quickly facilitate goals-of-care (GOC) conversations, advance care planning, and hospice referrals amid time constraints and high-acuity challenges.
Statistics from Finland, provided by the Contact Point for Cross-Border Health Care in Finland and Kela (the Social Insurance Institution of Finland) include information on cross-border healthcare, European Health Insurance Card (EHIC), medical care costs incured abroad and their reimbursements, and prior authorisations for seeking treatment abroad.
Universal Balance Gesture
Benefits:
Your right thumb represents the fire element and the manipura chakra while your little finger is associated with water and the swadhisthana chakra, and your ring finger with the earth element and the muladhara chakra.
Extending these fingers balances your three lower chakras.
AI presentation Practical Tips for doctors Mohali Jul 2024.pptxGaurav Gupta
Introduction:
- The rapid advancement of artificial intelligence (AI) is transforming healthcare
- Doctors must adapt to integrate AI tools effectively into their practice
- This presentation provides practical tips for leveraging AI to enhance patient care
1. Understanding AI in Medicine:
- Types of AI: Machine learning, deep learning, natural language processing
- Key applications: Diagnosis, treatment planning, imaging analysis, drug discovery
- Limitations: Data quality issues, bias, lack of contextual understanding
2. AI-Assisted Diagnosis:
- Using AI tools to analyze patient data and suggest potential diagnoses
- Combining AI insights with clinical expertise for more accurate diagnoses
- Case studies: AI in radiology, pathology, and rare disease identification
3. Treatment Planning with AI:
- AI-powered clinical decision support systems
- Personalized treatment recommendations based on patient data and medical literature
- Monitoring treatment efficacy and adjusting plans in real-time
4. AI in Medical Imaging:
- AI-enhanced image analysis for faster and more accurate interpretations
- Automated detection of abnormalities in X-rays, MRIs, and CT scans
- Reducing radiologist workload and improving early detection of diseases
5. Staying Updated with AI Advancements:
- Continuous learning through online courses and workshops
- Participating in AI-focused medical conferences
- Collaborating with AI researchers and developers
6. Patient Communication:
- Explaining AI's role in diagnosis and treatment to patients
- Addressing patient concerns about AI in healthcare
- Using AI to enhance patient education and engagement
7. Future Trends:
- AI in precision medicine and genomics
- Wearable devices and AI for remote patient monitoring
- AI-powered virtual health assistants and chatbots
8. Overcoming Implementation Challenges:
- Addressing resistance to change within medical teams
- Managing the learning curve for new AI technologies
- Ensuring interoperability with existing systems
Conclusion:
- AI is a powerful tool to augment, not replace, medical professionals
- Embracing AI can lead to improved patient outcomes and more efficient healthcare delivery
- Doctors must actively engage with AI to shape its development and application in medicine
Key Takeaways:
1. Familiarize yourself with AI capabilities and limitations in healthcare
2. Integrate AI tools gradually into your clinical workflow
3. Use AI to enhance decision-making, not as a substitute for clinical judgment
4. Stay informed about AI advancements and ethical considerations
5. Communicate clearly with patients about AI's role in their care
By following these practical tips, doctors can effectively leverage AI to improve patient care, streamline workflows, and stay at the forefront of medical innovation. As AI continues to evolve, it's crucial for medical professionals to adapt and harness its potential to transform healthcare delivery.
The Future of Ophthalmology: Dr. David Greene's Stem Cell Vision RestorationDr. David Greene Arizona
The future of ophthalmology is bright, thanks in large part to the pioneering work of Dr. David Greene. His advancements in stem cell therapy offer a beacon of hope for those suffering from vision loss. As research progresses, we can look forward to a world where restoring sight is not just a possibility, but a reality.
A Combinatorial Antihypertensive Drug (Reserpine and Hydrazine) Does Not Caus...CrimsonPublishersGGS
Background and objectives: Reserpine, a traditional Indian Ayurvedic medicine, is approved by the FDA to treat hypertension and for treatment
resistant psychosis. The major reported side effect of reserpine is depression. Hence, hypertensive patients on prolonged reserpine treatment were
evaluated for occurrence of depression.
Methods: One-time cross-sectional evaluation was done in 104 subjects on reserpine and 105 controls, who were matched for age (majority being
between 50- 70 years old), sex, education, and social background. The Control group had no chronic disease and the treatment group comprised of
hypertensive patients who had received reserpine as Adelphane (0.1mg reserpine and 10mg of hydralazine) or Adelphane Esidrex [Novaritis (Basel,
Switzerland)] for more than 1 year. Both the groups were asked to answer (and were rated by) Hamilton Depression Rating Scale (HDRS-17-items
version). The results were scored, statistically analyzed and plotted with Sigma Plot.
TEST BANK For Auditing & Assurance Services ASystematic Approach, 12th Editio...rightmanforbloodline
TEST BANK For Auditing & Assurance Services ASystematic Approach, 12th EditionChapters 1 - 21 Complete.pdf
TEST BANK For Auditing & Assurance Services ASystematic Approach, 12th EditionChapters 1 - 21 Complete.pdf
NATURAL, COLORFUL, YUMMY COSMETICS BRAND FOR YOUR BEAUTYzcodebro
Organic Mimi is a real treat for skin and hair care. A healthy and pleasant pampering experience when you want to indulge yourself with organic natural ingredients for skin beauty and delicious fragrances for cheerful mi-mi mood. Our products are "no-fuss": pure formulations and simple application ensure your skin's basic needs for hydration, nourishment and protection are covered. Fun packaging, reminiscent of ice-cream cups, and mimi-aromatherapy turn your everyday skincare routine into a genuine beauty ritual causing beauty addiction
2. Q4 2023 Results
Play to Win
February 1, 2024
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
3. 3
Forward-looking statements
Investor Relations
This document contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-
looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying
assumptions, statements regarding plans, business transformations, objectives, intentions and expectations with respect to future financial
results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking
statements are generally identified by the words “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans”, “potential”, “outlook”,
“guidance” and similar expressions. Although Sanofi’s management believes that the expectations reflected in such forward-looking statements
are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of
which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially
from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include
among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing,
decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological
application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the
availability or commercial potential of such product candidates, the fact that product candidates if approved may not be commercially successful,
the future approval and commercial success of therapeutic alternatives, Sanofi’s ability to benefit from external growth opportunities, to
complete capital markets or other transactions and/or obtain regulatory clearances, risks associated with developing standalone businesses,
risks associated with intellectual property and any related pending or future litigation and the ultimate outcome of such litigation, trends in
exchange rates and prevailing interest rates, volatile economic and capital market conditions, cost containment initiatives and subsequent
changes thereto, and the impact that pandemics, political disruption or armed conflicts or other global crises may have on us, our customers,
suppliers, vendors, and other business partners, and the financial condition of any one of them, as well as on our employees and on the global
economy as a whole. The risks and uncertainties also include the uncertainties discussed or identified in the public filings with the SEC and the
AMF made by Sanofi, including those listed under “Risk Factors” and “Cautionary Statement Regarding Forward-Looking Statements” in Sanofi’s
annual report on Form 20-F for the year ended December 31, 2022. Other than as required by applicable law, Sanofi does not undertake any
obligation to update or revise any forward-looking information or statements.
Brand names appearing in this presentation are trademarks of Sanofi and/or its affiliates. Not all trademarks related to products under
development have been approved as of the date of this presentation by the relevant health authorities.
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
4. 4
Agenda
Investor Relations
Launch engine to fuel
sustainable growth
Paul Hudson
R&D update
Houman Ashrafian
Biopharma update
Brian Foard, Thomas Triomphe,
Olivier Charmeil
Consumer Healthcare update
Julie Van Ongevalle
Financial performance
and outlook 2024
Jean-Baptiste de Chatillon
01
03
04
02
05
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
6. 6
FY 2023: Launch performance and Dupixent drive strong growth
of Specialty Care and Vaccines
Investor Relations
All growth at CER unless footnoted. 1. Beyfortus, ALTUVIIIO, Tzield.
Specialty Care
€18.0bn
+14.2%
GenMed
€12.4bn
-7.1%
Vaccines
€7.5bn
+8.3%
€5.2bn
+6.3%
Consumer
Healthcare
Core assets
€6.3bn
+3.3%
• FY 2023 sales of €43.1bn
(+5.3%)
• Dupixent adding €2.8bn (at CER)
• More than offsetting the loss
of €1.1bn of Aubagio sales to
generics (LoE)
- FY 2023 sales growth w/o
Aubagio of 8.1%
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
7. 7
Launch engine delivering
Investor Relations
1. Proprietary Specialty Pharmacy data and Sanofi analysis.
Protect all infants against RSV
in their first season
Strong ramp up in launch markets
Potential new standard
protection with weekly dosing
Leading share in switches1
in the U.S. at the end of Q4
First and only therapy to delay
onset of Type 1 diabetes
Expanding awareness and
screening programs
€731m
collectively
in first year
of launch
2023
2023 key launches far exceeded originally
communicated sales expectations of €400m
72
91
159
227
310
381
425
547
25
Beyfortus Nexviazyme Sarclisa Rezurock Cablivi
Altuviiio Xenpozyme Enjaymo Tzield
Total of >€2.2bn sales in 2023
from all Biopharma launches
combined (in €m)
2021 2022 2023
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
8. 8
Building an Immunology Powerhouse driven by new launches,
Dupixent and Vaccines
Investor Relations
Barring unforeseen events. 1. Risk-adjusted net sales at CER, including Pharma already launched and Potential launches (tolebrutinib, itepekimab, amlitelimab, frexalimab, rilzabrutinib, lunsekimig, Oral TNFR1si).
Net
sales
in
€bn
Pharma launches
ALTUVIIIO, Cablivi, Enjaymo,
Nexviazyme, Tzield, Rezurock,
Sarclisa, Xenpozyme
Sanofi Vaccines
sales by 2030
>€10bn
2017 2018 2019 2020 2021 2022 2023 2024E 2030E
~€13bn
€10.7bn
€8.3bn
€5.2bn
€3.5bn
€2.1bn
€0.8bn
€0.2bn
Sales contribution
from Pharma launches
incl. pipeline by 20301
>€10bn
Reaching almost
€1.7bn of sales
in 2023
Low
double-digit
growth
(2023-2030
CAGR)
Vaccines GBU
Sales of €7.5bn
in 2023, including
>€500m in its
first year of launch
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
9. 9
Preparing for the introduction of potential transformative COPD
therapies with an expected launch of Dupixent later this year
Investor Relations
1. G7 countries: U.S., France, Germany, Italy, Japan, UK, Canada; GOLD criteria Group E and uncontrolled with triple therapy or LAMA/LABA contraindicated to ICS. 2. Itepekimab not yet approved by any regulatory agency. 3. Dupixent is under
investigation and not yet approved for COPD and is being studied in patients with uncontrolled COPD treated with current SoC triple therapy among GOLD E. Patient populations exclude never smokers.
Patient population G71 – 2035e
itepekimab
First-in-class
anti-IL-33
2023 2024 2025
First-in-disease
U.S. submission EU submission CN submission
itepekimab2
~1,139K
patients
Dupixent®3
and
itepekimab2
~640K patients
Dupixent®3
only
~270K patients
Current
smokers
(30%)
Former
smokers
(70%)
Non-Type 2 Type 2
üüü
Boreas
Notus
Aerify 1
Aerify 2
Dupixent and itepekimab have the potential to
address different COPD populations with limited overlap
COPD peak sales potential for Dupixent
and itepekimab of >€5bn combined
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
10. 10
Play to win priorities in 2024
Investor Relations
Dupixent is under investigation and not yet approved for COPD.
Launch
Excellence
Pipeline
Execution
Reallocation of pipeline
resources (i.e., from oncology
to immunology)
Centralization, hub strategy
Smart spending
Cost
Reallocation
Potential expansion
into COPD
Tolebrutinib
RMS/nrSPMS
Rilzabrutinib
ITP
18 Phase 2 and
12 Phase 3
starts
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
11. 11
Advancing our commitments to address climate change and
leading the SMI Patient Care Pathways working group
Investor Relations
2023
2030
Carbon
neutrality
trajectory
2045
Net zero
emissions
-90% GHG reduction vs. 2019, across our operations (Scope 1&2)
and our entire value chain (Scope 3)
Reduce
GHG emissions
from our activities
(Scope 1&2)
Source
renewable
electricity
Expand
eco-car
fleet
Reduce
GHG emissions
from our activities
(Scope 3)
-38%
vs. 2019
-7%
vs. 2019
79%
vs. 2019
43%
vs. 2019
-55%
vs. 2019
-30%
vs. 2019
100%
vs. 2019
100%
vs. 2019
Patient Care Pathway aims to
reduce the carbon footprint of the
healthcare system and improve
health outcome.
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
13. 13
Outstanding pipeline news flow presented at the R&D Day
Investor Relations
lunsekimig
Demonstrated Proof of
Mechanism in Phase 1
study in Asthma
Dupixent
Positive Phase 3
results with
dupilumab in COPD
(BOREAS study)
itepekimab
Passed futility analysis
in COPD (AERIFY 1 &
2 studies)
frexalimab
Demonstrated 89%
reduction in new lesions
in Phase 2 study in
Multiple Sclerosis
amlitelimab
Primary endpoint met
in Phase 2 Atopic
Dermatitis study
PCV21 vaccine
Positive safety and
immunogenicity data
from the Phase 1/2
pediatric program
RSV toddler vaccine
Positive safety and
immune response data
from the Phase 1/2 trial
E. coli vaccine
Sanofi and JNJ announce
collaboration to
develop novel ExPEC
vaccine
TL1A
Sanofi and Teva announce
collaboration to deliver
inflammatory bowel
disease treatment
Oral TNFR1si
Demonstrated Proof
of Mechanism in
Phase 1 study in
Psoriasis
rilzabrutinib
Primary endpoints met
in Phase 2 CSU, with
improvements in other
secondary endpoints
Dupixent
Positive Phase 3 results
with dupilumab in COPD
(NOTUS study)
Sarclisa
Primary endpoints
met in Phase 3 1L
MM (IMROZ study)
R&D Day
December
2023
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Growth engine Outlook 2024
Financial performance Appendices
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
14. H1 2024 H2 2024
Dupixent
COPD U.S./EU Approval
CSU (Study C) Pivotal trial readout
tolebrutinib
RMS (GEMINI 1/2) Pivotal trial readout
nrSPMS (HERCULES) Pivotal trial readout
amlitelimab Asthma Phase 2 readout
rilzabrutinib
ITP (LUNA 3) Pivotal trial readout
Asthma Phase 2 readout (HD)
Sarclisa
1L MM Ti (IMROZ) U.S. Submission
SubQ 2/3L MM (IRAKLIA) Pivotal trial readout
14
Expected major R&D milestones in 2024
Investor Relations
As of December 31, 2023, barring unforeseen events. For abbreviations see slide 61.
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Growth engine Outlook 2024
Financial performance Appendices
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
15. Ph2
amlitelimab HS
lunsekimig Asthma
Oral TNFR1si Psoriasis
Oral TNFR1si RA
frexalimab T1D
amlitelimab SSc
SP0256 RSV OA Combo
Barring unforeseen events. .
15
Ph3
amlitelimab AD
frexalimab RMS
frexalimab nrSPMS
Dupixent Asthma ped
SP0125 RSV toddler
riliprubart CIDP Refractory
riliprubart CIDP IVIg treated
Investor Relations
Ph2
amlitelimab Celiac
amlitelimab AA
lunsekimig AD
lunsekimig Asthma high risk
lunsekimig CRSwNP
Oral TNFR1si IBD
Ph3
rilzabrutinib CSU
rilzabrutinib PN
SAR443820 ALS
SP0202 PCV21 pediatric
SP0218 Yellow fever
H1 H2
15
Unprecedented pipeline of blockbuster opportunities
Starting multiple Phase 3 and Phase 2 projects in 2024
First-patient in achieved
>35 Phase 3 projects in pipeline by 2025
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Growth engine Outlook 2024
Financial performance Appendices
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
16. Peak investment
Multiple Phase 3 trials
launching in parallel
Focus
Breadth of platforms,
sites and therapeutic areas
Pipeline sustainability
Fueled by in-house research
and external innovation
16
Key topics to prepare for the future
Investor Relations
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
17. Strategic fit
17
INBRX-101 acquisition to add innovative asset with blockbuster
potential to rare disease portfolio addressing AAT deficiency
Investor Relations
Acquisition subject to customary closing conditions.
INBRX-101
• Adding mid-stage asset in Rare Diseases
• Expansion of our immune-mediated respiratory portfolio
Unmet need
Differentiated
clinical data
• Recombinant AAT Fc with potential best-in-class profile
• Ph1 trial completed, achieving normal AAT levels
• Potential for less frequent dosing and favorable safety
profile, improving SOC plasma-derived AAT therapy
• Fast Track designation by FDA in AATD in May 2023
• Proven mechanism of action with Ph2b data in H2 2025,
potential for accelerated approval
• Potential eligible U.S. diagnosed patient population 20-35k
• Potential eligible EU diagnosed patient population 15-25k
Blockbuster
potential
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Growth engine Outlook 2024
Financial performance Appendices
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
19. Specialty Care performance
Investor Relations
Dupixent
€2,990m
+31.3%
Rare Diseases1
€1,266m
+14.5%
€4.7bn sales +13.7%
Neurology,
Oncology &
Rheumatology
€458m
-39.5%
Dupixent
Continued strong demand-driven growth in
approved indications across all geographies
Rare Diseases
• ALTUVIIIO launch execution and Alprolix
performance drive double-digit growth of
hemophilia franchise
• Robust growth of all ERT franchises supported
by new patient accruals and continued launch
rollout of Nexviazyme and Xenpozyme
• Aubagio LoE sales erosion with full quarter
of exposure to generics in the U.S. and Europe
19
Q4 2023
All growth at CER unless footnoted. Growth rate is vs. Q4 2022.
1. Rare Diseases includes Rare Blood Disorders.
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
Vaccines
Specialty Care GenMed
20. 20
Dupixent strong performance in 2023; expected to deliver
~€13bn in 2024
Investor Relations
1. All percentage growth at CER. 2. IQVIA, Dec 2023.
Global Dupixent sales (in € m)
U.S.
(+28%)1
Ex-U.S.
(+43%)1
1,170
Q1 Q2 Q3 Q4
2,402 2,316
2,562
2,847
2,990
6,346
8,145
1,947
2,570
2022 2023
8,293
10,715
+34%1
2023
FY performance highlights
Recent progress
• Worldwide growth of +34%, with each
major geography (U.S., Europe, RoW region)
exceeding >30% growth
• #1 U.S. NBRx share in all 5 approved indications2
• COPD submission completed (EU, U.S., CN)
• Asthma approved in China
• U.S. AD label update unique hand
and/or foot atopic dermatitis efficacy
and safety data
2022
Q4
Ex-U.S. U.S.
2,299
691
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Growth engine Outlook 2024
Financial performance Appendices
Vaccines
Specialty Care GenMed
21. 21
Top choice for switches driven by efficacy profile
Investor Relations
1. Proprietary Specialty Pharmacy data and Sanofi analysis. 2. Including patients on free trials.
Cumulative patient number
with ALTUVIIIO Prescription2
Accelerating ALTUVIIIO U.S. launch performance
Q2 Q3 Q4
2023
250
1,100+
Strong switch dynamics
Capturing >50% of switches1 in total U.S.
hem A market, up from 40% at the end of Q3
Growing overall portfolio
~2/3 of switches from competition
Expansion ex-U.S.
Rapid Japan uptake with >30 patients
in first few weeks of launch in late Q4
650+
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Growth engine Outlook 2024
Financial performance Appendices
Vaccines
Specialty Care GenMed
22. Booster vaccines
€139m
-1.4%
Meningitis,
Travel &
Endemic
€242m
+10.4%
22
Vaccines performance
Investor Relations
All growth at CER unless footnoted. Growth rate is vs. Q4 2022.
Polio/
Pertussis/Hib
€434m
+3.4%
Influenza
€741m
-4.0%
Others
€20m
-76.1%
€2.0bn +21.1%
sales
Significant contribution from Beyfortus uptake
due to “All Infant Protection” recommendation
in launch countries (U.S., France and Spain)
Influenza sales reflect lower immunization
rates and increased U.S. competition
Meningitis and PPH franchises benefited
from public order pattern in the quarter
RSV
€410m
Q4 2023
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
Vaccines
Specialty Care GenMed
23. 11% 10%
38%
PCV Rotavirus Beyfortus
Beyfortus – unprecedented pediatric immunization uptake
Beyfortus lays foundation for best-in-class RSV portfolio
• Successful implementation
for broad infant population
with high immunization rates
- ~35% in the U.S. and France
- 90% in Spain, with real-world
evidence data from Galicia1
showing significant
hospitalization reduction
• Harmonie Ph3b results
published in NEJM2
23
• U.S. Fast Track Designation in Oct 2023
• Phase 1/2 RSV-hMPV initiated in Nov
2023
• U.S. Fast Track Designation in
2020 and EU PRIME in Dec 2023
• Phase 3 start in Q1 2024
RSV Toddler for 2nd season onwards
RSV Older Adult combination
Investor Relations
23
RSV new development
Beyfortus launch
Innovative vaccines for all target populations
1. (NIRSE-GAL study: evolution of Immunization Coverage with nirsevimab (nirsegal.es)). 2. https://www.nejm.org/doi/full/10.1056/NEJMoa2309189.
U.S. uptake in the first 6 months
surpasses previous pediatric
immunization benchmarks
PCV (Prevnar) and Rotavirus (Rotateq) data from IQVIA DDD for
private doses, and CDC data for public doses. Beyfortus 2023-
2024 season immunization rates projected from sales data, to be
confirmed after RSV season
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
Vaccines
Specialty Care GenMed
24. 24
GenMed performance
Investor Relations
All growth at CER unless footnoted. Growth rate is vs. Q4 2022.
€3.0bn -2.4%
sales
Industrial
sales
€176m
+1.1%
Core assets
€1,576m
+6.3%
Non-core
assets
€1,252m
-11.6%
Core assets
• Growth of 6.3% in Q4 2023
• Continued expansion of Rezurock offset by
Mozobil LoE in the U.S.
• Robust growth of Toujeo, Plavix in China
and Praluent in EU
Non-core assets
• Lantus impacted by significant U.S. net price
decline due to unfavorable channel mix and
VBP China
Portfolio streamlining
• Portfolio streamlining impact sales -2.6ppt
(around €87m)
Q4 2023
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Growth engine Outlook 2024
Financial performance Appendices
Vaccines
Specialty Care GenMed
25. 25
TZIELD - a catalyst for change within Autoimmune T1D
Investor Relations
1. Captures net sales after April 27, 2023 (6m in Q2, 9m in Q3, 10m in Q4). 2. Testing of 3+ autoantibodies Nov 2023 YTD vs. Nov 2022 YTD.
• 168 people infused
with TZIELD
+25% growth
(Q4 vs. Q3), time to
infusion around 30 days
• 216m U.S. lives
covered in plans
Since acquisition
€25m sales1
Solid early
performance
Screening
accelerates
• National screening
campaign launched
in Times Square
Screening grew
+31% driven
by endocrinologists2
• ADA guidelines
updated
Recommend T1D
family screening
TZIELD label expansion
and new horizons in aT1D
• Regulatory
interaction with
FDA & EMA in Q1'24
FPI for the Phase 2
frexalimab study
T1D indication
The 1 Pledge launch in Times
Square (U.S.) with Grammy Awards
winner Usher
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
Vaccines
Specialty Care GenMed
30. 30
Q4 2023 performance
Investor Relations
All growth at CER unless footnoted.
• Q4 sales up 9.3%
• Double-digit growth of Specialty
Care driven by Dupixent and
Rare Diseases
• Beyfortus uptake drives
strong quarter for Vaccines
• GenMed anticipated deceleration
of decline with U.S. glargine
business still down double-digit
• CHC growth from key categories
and acquisition (Qunol)
€4.7bn
+13.7%
€3.0bn
-2.4%
€2.0bn
+21.1%
Core assets
€1.6bn
+6.3%
€1.2bn
+8.5%
Consumer
Healthcare
Specialty Care GenMed
Vaccines
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
31. 31
Q4 Group P&L
Investor Relations
All growth at CER. 1. Margin at published rate.
31
Sales growth
+9.3%
Gross margin
+2.8ppt, due to product
mix and COVID-19 vaccine
revenues
BOI margin
-1.7ppt (at published rates)
mainly due to a decrease
in capital gains related to
product disposals as compared
to the same quarter of last year
€m Q4 2023 Q4 2022 % Change
Net Sales 10,919 10,725 +9.3%
Other revenues 1,282 731 +90.8%
Gross profit 8,167 7,722 +13.5%
Gross margin % 74.8%1 72.0%1
R&D (1,872) (1,823) +6.6%
SG&A (2,931) (2,895) +7.4%
Operating Expenses (4,803) (4,718) +7.1%
Other current operating income & expenses (821) (276) +219.6%
Business Operating Income 2,583 2,724 +5.3%
Business operating margin 23.7%1 25.4%1
Effective tax rate 18.1% 20.6%
Total Business Net Income 2,083 2,141 +8.2%
Average number of shares 1,253.6 1,254.0
Business EPS 1.66 1.71 +8.2%
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Growth engine Outlook 2024
Financial performance Appendices
32. 32
FY 2023 Group P&L
Investor Relations
All growth at CER. 1. Margin at published rate.
32
Sales growth
+5.3%
Gross margin
+1.1ppt, of which 0.8ppt
due to COVID-19 vaccine
related sales and revenues
(non-recurring)
BOI margin
-0.9ppt (at published rate)
due to currency, stable at CER
EPS
+5.4%, in-line
with guidance
€m FY 2023 FY 2022 % Change
Net Sales 43,070 42,997 +5.3%
Other revenues 3,374 2,392 +50.0%
Gross profit 32,228 31,697 +7.0%
Gross margin % 74.8%1 73.7%1
R&D (6,728) (6,706) +3.0%
SG&A (10,692) (10,492) +6.1%
Operating Expenses (17,420) (17,198) +4.9%
Other current operating income & expenses (2,224) (1,514) +55.9%
Business Operating Income 12,670 13,040 +4.3%
Business operating margin 29.4%1 30.3%1
Effective tax rate 18.8% 19.3%
Total Business Net Income 10,155 10,341 +5.5%
Average number of shares 1,251.7 1,251.9
Business EPS 8.11 8.26 +5.4%
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Growth engine Outlook 2024
Financial performance Appendices
33. 33
Proposed dividend of €3.76
Investor Relations
Subject to AGM’s approval on April 30, 2024.
1994 2023
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
35. 35
Strategic cost initiatives, targeting total up to €2bn from 2024
to end of 2025, to be reallocated in majority
Investor Relations
Priorities
In pursuit of first-in-class/
best-in-class pipeline assets,
active reallocation of
pipeline resources
(e.g., from oncology
to immunology)
Smart
spending
Further leverage
procurement to generate
additional savings
Operational
excellence
Optimize country setup,
increase degree of
centralization by expanding
hub strategy, refocus
R&D infrastructures and
technology platforms
€0.7bn
€0.6bn
€0.7bn
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
36. 36
Expected business dynamics in 2024 with Q1 marked by
high base of comparison
Investor Relations
Barring unforeseen events.
FY 2024 Q1 2024
Sales • Dupixent expected to reach approximately €13bn
• Vaccines sales expected to grow mid-single-digit
• Aubagio LoE impact, mainly in H1
• GenMed divestment impact of ~€300m
• Dupixent annual step-up in U.S. copay assistance program
• High rate of Aubagio generic erosion in U.S. and Europe
• High base in Vaccines due to 2023 COVID-19 vaccine sales
(€167m in Q1 2023)
• Limited supply of Beyfortus
• High base of Lantus in the U.S. in Q1 2023
(versus Q2, Q3 and Q4 2023)
P&L • Gross margin slightly declining
• OPEX growth due to step-up in development spending
• Capital gains from product divestments expected >€500m
• Tax rate of 21% (vs. 18.8% in 2023)
• No COVID-19 vaccine revenues (€62m in Q1 2023)
• OPEX growth due to increase in development spending
• High capital gains from product divestments (€307m)
in Q1 2023
• Tax rate of around 21% (vs. 19.0% in Q1 2023)
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Growth engine Outlook 2024
Financial performance Appendices
37. 37
FY 2024 guidance
Investor Relations
Barring unforeseen events. 1. Based on January 2024 average rates.
37
approximately
-3.5% to -4.5%
Currency
impact1
EPS growth
Low single-digit
EPS decline
(roughly stable
at comparable
tax rate)
R&D update Biopharma update Consumer Healthcare update
Growth engine Outlook 2024
Financial performance Appendices
49. 49 Investor Relations
nirsevimab/Beyfortus
Initial agreement Sanofi-AstraZeneca (March 2017)
Major markets (U.S., FR, DE, ES, IT, UK, JP) Rest of world markets
Net sales Sanofi consolidates worldwide net sales
Cost of sales Sanofi consolidates worldwide cost of sales (finished goods purchased from AstraZeneca)
R&D AstraZeneca & Sanofi share the alliance development costs 50/50
SG&A
Sanofi expenses 100% of its SG&A (and further shares 50/50
in OOIE)
Sanofi expenses 100% of its SG&A
(not shared)
Other operating
income and expenses
Alliance
profit & loss
Sanofi shares with AstraZeneca the alliance commercial
profit & loss 50/50
Sanofi pays to AstraZeneca
25% of net revenues
Intangible asset
Beyfortus
(amortized below
BNI over useful life)
Upfront EUR 120m paid by Sanofi to AstraZeneca upon closing (March 2017)
Regulatory
milestones
AstraZeneca received from Sanofi EUR 55m and will receive EUR 65m for BLA Approval in the U.S.
Sales
milestones
AstraZeneca to receive up to EUR 375m sales milestones from Sanofi, upon achievement of certain sales related milestones
Above BNI Below BNI
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Growth engine Outlook 2024
Financial performance Appendices
Financial appendices ESG appendices Abbreviations Collaborations
R&D appendices
50. 50 Investor Relations
Sanofi accounting of nirsevimab/Beyfortus
Updated and new agreements Sanofi-AstraZeneca and Sanofi-Sobi (April 2023)
U.S. Major markets (CN, FR, DE, ES, IT, UK, JP) Rest of world markets
Net sales Sanofi consolidates worldwide net sales
Cost of sales Sanofi consolidates worldwide cost of sales (finished goods purchased from AstraZeneca)
R&D Sanofi bears 100% of the costs from April 2023 onward AstraZeneca & Sanofi share the alliance development costs
SG&A Sanofi bears 100% of the costs from April 2023 onward Sanofi expenses 100% of its SG&A
(and further shares 50/50 in OOIE)
Sanofi expenses 100% of
its SG&A (not shared)
Other
operating
income and
expenses
Alliance profit
& loss
Sanofi consolidates 100% of the economics in the U.S. from
April 2023 onward
Sanofi shares with AstraZeneca the alliance
commercial profit & loss 50/50
Sanofi pays to AstraZeneca
25% of net revenues
Intangible
asset
Beyfortus
(amortized
below BNI
over useful
life)
Upfront EUR 120M paid by Sanofi to AstraZeneca upon closing (March 2017)
Regulatory milestones AstraZeneca received from Sanofi EUR 120m
Sales milestones AstraZeneca to receive up to EUR 375m sales milestones from Sanofi, upon achievement of certain sales related milestones.
A first sales milestone of EUR 25m was triggered in Q4 2023
Additional rights
from AstraZeneca
(amendment April 2023)
Sanofi records price of U.S rights to obtain full commercial control (Fair Value)
Royalty Agreement Sanofi–Sobi (April 2023)
Financial liability (Sobi) Initial recognition at Fair Value of U.S. royalties due to Sobi - Liability reduced by royalty payments over time -
Subsequent re-measurement in P&L below BNI
Updated agreement Sanofi-AstraZeneca
Above BNI Below BNI
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52. Investor Relations
1. Credit ratings reaffirmed: Moody’s A1/stable, S&P AA/stable, Scope AA/stable as of December 31, 2023. 2. Including derivatives used to manage net debt: €142m at December 31, 2022, and €111m at December 31, 2023.
3. Effective January 1, 2019, net debt does not include lease liabilities following the first-time application of IFRS16. 4. Including €593m use of funds from acquisition of treasury shares, -€195m of issuance of Sanofi shares and €498m of other items.
-997
896
1,113
1,236
4,454
Dividends paid
to shareholders
of Sanofi
6,437
-9,830
4,484
7,793
Net Debt
December 31,
20222,3
Net Debt
December 31,
20232,3
FCF before
restructuring,
acquisitions
& disposals
Proceeds
from
disposals
Asset
acquisition
Restructuring
& similar
items
Other4
Net debt evolution in 20231
€ millions
52
Acquisitions of
investments in
consolidated
undertakings
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All growth at CER. 1. Margin at published rate.
Q4 CHC P&L
53
€m Q4 2023 Q4 2022 % Change
Net Sales 1,215 1,242 +8.5%
Other revenues 14 16 -12.5%
Gross profit 747 767 +9.0%
Gross margin % 61.5%1 61.8%1
R&D (56) (61) -4.9%
SG&A (473) (448) +12.9%
Operating Expenses (529) (509) +10.8%
Other current operating income & expenses 84 38
Business Operating Income 304 295 +22.7%
Business operating margin 25.0%1 23.8%1
Sales growth
+8.5% due to Qunol
acquisition and continued
strong business performance
of Digestive Wellness
SG&A
+12.9% driven by increased
investment into advertising
and promotion of key brands
BOI margin
+1.2ppt due to the
acquisition of Qunol
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2024 currency sensitivity and Q4 2023 currency exposure
US $ 46.0%
Euro € 21.0%
Chinese Yuan 5.7%
Japanese Yen 3.7%
Brazilian Real 2.0%
Mexican pesos 2.7%
Canadian $ 1.6%
British Pound 1.2%
Australian $ 1.2%
South Korean won 1.1%
Others 13.8%
Currency exposure on Q4 2023 sales
2024 Business EPS currency sensitivity
Currency Variation Business EPS sensitivity
U.S. Dollar + 0.05 USD/EUR - EUR 0.17
Japanese Yen + 5 JPY/EUR - EUR 0.02
Chinese Yuan + 0.2 CNY/EUR - EUR 0.02
Brazilian Real + 0.4 BRL/EUR - EUR 0.01
Russian Ruble + 10 RUB/EUR - EUR 0.01
Currency average rates
Q4 2022 Q4 2023 % change
EUR/USD 1.021 1.076 +5.4%
EUR/JPY 144.203 159.030 +10.3%
EUR/CNY 7.264 7.778 +7.1%
EUR/BRL 5.372 5.329 -0.8%
EUR/RUB 64.072 99.644 +55.5%
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Sanofi ESG FY achievements
Ambition Progress
FY 2023 FY 2022
Sanofi
Global Health
Reach 1.5 million NCD patients
by 2026 (cumulative since 2022)
and 2 million by 2030
261,977 patients treated in
31 countries
33 active healthcare partnerships in
15 countries
3 investment though the
Impact fund
185,151 patients treated
in 28 countries
19 active healthcare
partnerships in
11 countries
1 investment though
the Impact fund
Vials
donations
Donate 100,000 vials a year to
treat people with rare diseases,
via the Humanitarian Program
launched by Sanofi Specialty Care
1,163 patients treated
124,136 vials donated
1,122 patients treated
121,025 vials donated
Global
access plans
Develop a Global access plan
for all new products to make
them available within two years
after first launch
8 Global Access plans initiated
or developed covering more than
12 indications
2 Global Access
Plans initiated
Affordable access
Figures presented are YTD.
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Sanofi ESG FY achievements
Ambition Progress
FY 2023 FY 2022
Sleeping
sickness
Develop and supply innovative
treatments to support the
elimination of sleeping sickness
by 2030
Data updated annually, next update
in Q2 2024
1.5 million patients tested
837 patients treated
Polio Provide inactivated polio vaccines
(IPV) to UNICEF for GAVI countries
to support polio eradication efforts
35 million IPV doses supplied
to UNICEF for GAVI countries
47 million IPV doses
supplied to UNICEF for
GAVI countries
Pediatric cancer
treatment
development
Develop innovative treatments to
eliminate cancer death in children
3 assets undergoing
pre-clinical assessment
First pediatric patient dosed with
1 clinical asset (less than 2 years
after the 1st adult patient was
dosed with this compound)
1 asset pre-clinical
assessment complete
1 asset in protocol
preparation for clinical
study
1 additional asset
identified for clinical
development
R&D for unmet needs
Figures presented are YTD.
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Sanofi ESG FY achievements
Ambition Progress
FY 2023 FY 2022
Climate change -
carbon footprint
CO2 emissions
55% reduction in scope 1&2
greenhouse gas emissions (CO2
equivalent) by 2030 (cumulative
vs 2019 baseline) to contribute to
carbon neutrality by 2030 and net
zero emissions by 2045 (all scopes)
38% GHG reduction
vs 2019
29% GHG reduction
vs 2019
Renewable
electricity
100% of renewable electricity
in all our sites by 2030
79% 62%
Eco-car
fleet
100% eco-car fleet in 2030 43% eco-car fleet 34% eco-car fleet
Blister free syringe
vaccines
100% blister free syringe
vaccines blister packs by 2027
39% blister free
syringe vaccines
33% blister free
syringe vaccines
Eco-design All new products to be
eco-designed by 2025
13 LCAs completed & 2 in progress
(new and marketed products)
7 LCAs completed &
1 in progress (new and
marketed products)
Eco design digital
solution launched
Planet Care
Figures presented are YTD.
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Sanofi ESG FY achievements
Ambition Progress
FY 2023 FY 2022
Global Gender
balance
Ambition of 50% of women
in senior leadership roles by 2025
44% 42%
Ambition of 40% of women
in executive roles by 2025
40% 37%
Engagement with
communities
Engage socially and economically
with all communities where
we operate
12,240 volunteers
75,376 hours
6,825 volunteers
46,976 hours
From Leaders
to Citizens
100% of Sanofi leaders have
CSR in their development path
71% of the leaders have
completed the eLearning phase
30% of the leaders have
completed the full program
>50% of the leaders
have completed the
eLearning phase
In and beyond the workplace
Figures presented are YTD.
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Scores assigned by the rating agencies are not equivalent.
Sanofi ESG ratings
Rating agencies
SCORE
87/100
21.2
Medium risk
79/100 A
Climate
Change: A
Water: A-
B 4.5/5 3.47/5 65/100
86/100 21.5 78/100 A A/A B 4.3/5 3.47/5 64/100
One of the highest
scores across all
sectors globally
81 points for its
solid fundamentals
& strong
preparedness
opinion of
6 points
19th
among 419
pharmaceutical
companies
Percentile of 99
within 348 scored
companies in the
industry
Score stable since
2021
Leading position 1st
decile of the
476 companies
in the industry
With very high
rating across the
3 pillars ESG
Top 10
company
1st
pharmaceutical
company out of 57
Score improving
since 2018
vs. previous rating
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Abbreviations
AA Alopecia Areata
AAT Alpha-1-Antitrypsin
AATD Alpha-1-Antitrypsin Deficiency
AAV Adeno-Associated Virus
Ab Antibody
AD Atopic Dermatitis
ADC Antibody Drug Conjugate
ALS Amyotrophic Lateral Sclerosis
BCMA B-Cell Maturation Antigen
BP Bullous Pemphigoid
BTK Bruton’s Tyrosine Kinase
CD Cluster of Differentiation
CEACAM5 Carcinoembryonic Antigen Cell Adhesion Molecule 5
CIDP Chronic Inflammatory Demyelinating
Polyneuropathy
COPD Chronic Obstructive Pulmonary Disease
CPUO Chronic Pruritus of Unknown Origin
CRC Colerectal Cancer
CRSwNP Chronic Rhinosinusitis with Nasal Polyps
CSR Corporate Social Responsibility
CSU Chronic Spontaneous Urticaria
ERT Enzyme Replacement Therapy
ExPEC Extraintestinal pathogenic E. coli
FGFR3 Fibroblast Growth Factor Receptor 3
GAA Acid Alpha-Glucosidase
GCS Glucosylceramide Synthase
GHG Greenhouse Gas
GPC3 Glypican-3
HD High Dose
HS Hidradenitis Suppurativa
HER2 Human Epidermal growth factor Receptor 2
hMPV human Metapneumovirus
IA Interim analysis
IBD Inflammatory Bowel Disease
IGF1R Insulin Like Growth Factor 1 Receptor
IIV Inactivated Influenza Vaccine
IL Interleukin
ILT2 Ig-like transcript 2
IPV Inactivated Poliomyelitis Vaccine
IRAK4 Interleukin 1 Receptor Associated Kinase 4
ITP Immune Thrombocytopenia
IVIg Intravenous Immunoglobulin
LCA Life Cycle Assessment
LOE Loss Of Exclusivity
mAb monoclonal Antibody
MM Multiple Myeloma
mRNA messenger RNA
MS Multiple Sclerosis
NCD Non-Communicable Diseases
NK Natural Killer
PAH Phenylalanine Hydroxylase
PCV Pneumococcal Conjugated Vaccine
PD1 Programmed Death protein 1
PN Prurigo Nodularis
PPMS Primary Progressive Multiple Sclerosis
PPH Polio, Pertussis, Haemophilus influenzae b (Hib)
QIV Quadrivalent Influenza Vaccine
RIPK1 Receptor-Interacting serine/threonine-Protein
Kinase 1
RA Rheumatoid Arthritis
RMS Relapsing Multiple Sclerosis
RNAi RNA interference
RRMM Relapsed-Refractory Multiple Myeloma
RSV Respiratory Syncytial Virus
SjS Sjogren's Syndrome
SLE Systemic Lupus Erythematosus
SOC Standard of care
SPMS Secondary-Progressive Multiple Sclerosis
SSc Systemic Sclerosis
TCR T Cell Receptor
Te Transplant eligible
TGFb Transforming Growth Factor beta
Ti Transplant ineligible
TL1A TNF-like Ligand 1A
TNF Tumor Necrosis Factor
TSLP Thymic Stromal Lymphopoietin
T1D Type 1 Diabetes
UC Ulcerative Colitis
VBP Volume-based Procurement
wAIHA Warn Autoimmune Hemolytic Anemia
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Collaborations
Ref Name Developed in collaboration with…
A Dupixent
itepekimab
Kevzara
Regeneron
B frexalimab ImmuNext
C ExPEC9V Vaccine Janssen Pharmaceuticals, Inc., a Johnson & Johnson company
D eclitasertib
SAR443820
Denali
E SAR444656 Kymera
F SAR447189 Teva Pharmaceuticals
G SP0202 SK
H SAR446159 ABL Bio
I SAR444836 Medicinova
J SAR444881 Biond Biologics
K SAR443579
SAR445514
Innate Pharma
L SAR445953 Seagen
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